Description: Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1) (CCT6A), transcript variant 1, mRNA. RefSeq Summary (NM_001762): The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]. Transcript (Including UTRs) Position: hg19 chr7:56,119,378-56,131,682 Size: 12,305 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr7:56,119,542-56,130,778 Size: 11,237 Coding Exon Count: 14
ID:TCPZ_HUMAN DESCRIPTION: RecName: Full=T-complex protein 1 subunit zeta; Short=TCP-1-zeta; AltName: Full=Acute morphine dependence-related protein 2; AltName: Full=CCT-zeta-1; AltName: Full=HTR3; AltName: Full=Tcp20; FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. SUBUNIT: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the TCP-1 chaperonin family. SEQUENCE CAUTION: Sequence=AAA58676.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40227
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0032212 positive regulation of telomere maintenance via telomerase GO:0050821 protein stabilization GO:0061077 chaperone-mediated protein folding GO:1904851 positive regulation of establishment of protein localization to telomere GO:1904871 positive regulation of protein localization to Cajal body GO:1904874 positive regulation of telomerase RNA localization to Cajal body
AB063318 - Homo sapiens MoDP-2, MoDP-3 mRNA for acute morphine dependence related protein 2, acute morphine dependence related peptide 3, complete cds. L27706 - Human chaperonin protein (Tcp20) gene complete cds. BC106941 - Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1), mRNA (cDNA clone IMAGE:40034020). BC106942 - Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1), mRNA (cDNA clone MGC:126215 IMAGE:40034021), complete cds. AK316230 - Homo sapiens cDNA, FLJ79129 complete cds, highly similar to T-complex protein 1 subunit zeta. AF385084 - Homo sapiens heat shock protein mRNA, complete cds. AK297751 - Homo sapiens cDNA FLJ53065 complete cds, highly similar to T-complex protein 1 subunit zeta. AK313819 - Homo sapiens cDNA, FLJ94440, highly similar to Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1)(CCT6A), mRNA. AK298371 - Homo sapiens cDNA FLJ52344 complete cds, highly similar to T-complex protein 1 subunit zeta. AB590066 - Synthetic construct DNA, clone: pFN21AB5054, Homo sapiens CCT6A gene for chaperonin containing TCP1, subunit 6A, without stop codon, in Flexi system. KJ890847 - Synthetic construct Homo sapiens clone ccsbBroadEn_00241 CCT6A gene, encodes complete protein. AB209728 - Homo sapiens mRNA for chaperonin containing TCP1, subunit 6A isoform a variant protein. AM295155 - Homo sapiens partial mRNA for chaperonin subunit 6A (CCT6A gene). DQ599192 - Homo sapiens piRNA piR-37258, complete sequence. DQ599636 - Homo sapiens piRNA piR-37702, complete sequence. M94083 - Human chaperonin-like protein (HTR3) mRNA, complete cds. DQ578910 - Homo sapiens piRNA piR-47022, complete sequence. LF206968 - JP 2014500723-A/14471: Polycomb-Associated Non-Coding RNAs. LF359771 - JP 2014500723-A/167274: Polycomb-Associated Non-Coding RNAs. LF359772 - JP 2014500723-A/167275: Polycomb-Associated Non-Coding RNAs. JD501317 - Sequence 482341 from Patent EP1572962. LF359773 - JP 2014500723-A/167276: Polycomb-Associated Non-Coding RNAs. JD038887 - Sequence 19911 from Patent EP1572962. JD038888 - Sequence 19912 from Patent EP1572962. LF359774 - JP 2014500723-A/167277: Polycomb-Associated Non-Coding RNAs. JD023436 - Sequence 4460 from Patent EP1572962. JD032768 - Sequence 13792 from Patent EP1572962. LF359775 - JP 2014500723-A/167278: Polycomb-Associated Non-Coding RNAs. JD024241 - Sequence 5265 from Patent EP1572962. JD034674 - Sequence 15698 from Patent EP1572962. LF359776 - JP 2014500723-A/167279: Polycomb-Associated Non-Coding RNAs. JD185270 - Sequence 166294 from Patent EP1572962. JD066217 - Sequence 47241 from Patent EP1572962. JD375289 - Sequence 356313 from Patent EP1572962. JD090041 - Sequence 71065 from Patent EP1572962. MA442545 - JP 2018138019-A/14471: Polycomb-Associated Non-Coding RNAs. MA595348 - JP 2018138019-A/167274: Polycomb-Associated Non-Coding RNAs. MA595349 - JP 2018138019-A/167275: Polycomb-Associated Non-Coding RNAs. MA595350 - JP 2018138019-A/167276: Polycomb-Associated Non-Coding RNAs. MA595351 - JP 2018138019-A/167277: Polycomb-Associated Non-Coding RNAs. MA595352 - JP 2018138019-A/167278: Polycomb-Associated Non-Coding RNAs. MA595353 - JP 2018138019-A/167279: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P40227 (Reactome details) participates in the following event(s):
R-HSA-389954 Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC R-HSA-389961 ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-391266 Association of CCT/TriC with sphingosine kinase 1 R-HSA-6814119 TRiC/CCT binds unfolded G-protein beta subunit R-HSA-390453 Hydrolysis of ATP and release of folded actin from CCT/TriC R-HSA-8850527 PDCL releases folded G-beta from TRiC/CCT R-HSA-8850539 Release of GNB5:RGS dimers from CCT/TRiC R-HSA-390459 Exchange of ADP for ATP in CCT/TriC:actin complex R-HSA-6814124 ATP binds G-protein beta associated TRiC/CCT R-HSA-8850529 RGS proteins bind GNB5 and CCT/TRiC R-HSA-8850534 PDCL promotes G-protein beta 5 folding R-HSA-6814121 PDCL binds G-protein beta and TRiC/CCT R-HSA-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-390450 Folding of actin by CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
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