Description: Homo sapiens motile sperm domain containing 3 (MOSPD3), transcript variant 1, mRNA. RefSeq Summary (NM_023948): This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:100,210,114-100,213,000 Size: 2,887 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr7:100,210,415-100,212,806 Size: 2,392 Coding Exon Count: 5
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MOSPD3 CDC HuGE Published Literature: MOSPD3 Positive Disease Associations: Erythrocyte Indices Related Studies:
Erythrocyte Indices Santhi K Ganesh et al. Nature genetics 2009, Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium., Nature genetics.
[PubMed 19862010]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75425
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.