Human Gene RETREG3 (uc002ial.2)
  Description: Homo sapiens family with sequence similarity 134, member C (RETREG3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:40,731,526-40,761,445 Size: 29,920 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr17:40,733,831-40,761,342 Size: 27,512 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:40,731,526-40,761,445)mRNA (may differ from genome)Protein (466 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F134C_HUMAN
DESCRIPTION: RecName: Full=Protein FAM134C;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the FAM134 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.91 RPKM in Testis
Total median expression: 691.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.60103-0.423 Picture PostScript Text
3' UTR -859.232305-0.373 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q86VR2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0010976 positive regulation of neuron projection development

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX648069 - Homo sapiens mRNA; cDNA DKFZp686D22210 (from clone DKFZp686D22210).
BX647175 - Homo sapiens mRNA; cDNA DKFZp686B1036 (from clone DKFZp686B1036).
AK091125 - Homo sapiens cDNA FLJ33806 fis, clone CTONG2000846.
AX746792 - Sequence 317 from Patent EP1308459.
AK057409 - Homo sapiens cDNA FLJ32847 fis, clone TESTI2003376.
JX982106 - Homo sapiens family with sequence similarity 134, member C variant (FAM134C) mRNA, 3' UTR.
BC024980 - Homo sapiens family with sequence similarity 134, member C, mRNA (cDNA clone IMAGE:4945004).
AK225797 - Homo sapiens mRNA for hypothetical protein LOC162427 variant, clone: FCC131B01.
BC049370 - Homo sapiens family with sequence similarity 134, member C, mRNA (cDNA clone MGC:57209 IMAGE:5263052), complete cds.
JD162078 - Sequence 143102 from Patent EP1572962.
JD516674 - Sequence 497698 from Patent EP1572962.
JD043882 - Sequence 24906 from Patent EP1572962.
JD274471 - Sequence 255495 from Patent EP1572962.
JD282484 - Sequence 263508 from Patent EP1572962.
JD268164 - Sequence 249188 from Patent EP1572962.
JD418131 - Sequence 399155 from Patent EP1572962.
JD330468 - Sequence 311492 from Patent EP1572962.
JD077606 - Sequence 58630 from Patent EP1572962.
JD440655 - Sequence 421679 from Patent EP1572962.
JD485905 - Sequence 466929 from Patent EP1572962.
JD224824 - Sequence 205848 from Patent EP1572962.
JD136037 - Sequence 117061 from Patent EP1572962.
JD337417 - Sequence 318441 from Patent EP1572962.
JD486409 - Sequence 467433 from Patent EP1572962.
JD166310 - Sequence 147334 from Patent EP1572962.
JD095825 - Sequence 76849 from Patent EP1572962.
JD521538 - Sequence 502562 from Patent EP1572962.
JD524205 - Sequence 505229 from Patent EP1572962.
DQ581348 - Homo sapiens piRNA piR-49460, complete sequence.
JD160652 - Sequence 141676 from Patent EP1572962.
JD206773 - Sequence 187797 from Patent EP1572962.
JD484222 - Sequence 465246 from Patent EP1572962.
JD563891 - Sequence 544915 from Patent EP1572962.
JD342092 - Sequence 323116 from Patent EP1572962.
JD064594 - Sequence 45618 from Patent EP1572962.
JD070365 - Sequence 51389 from Patent EP1572962.
JD213338 - Sequence 194362 from Patent EP1572962.
JD152348 - Sequence 133372 from Patent EP1572962.
JD258825 - Sequence 239849 from Patent EP1572962.
JD353095 - Sequence 334119 from Patent EP1572962.
JD476895 - Sequence 457919 from Patent EP1572962.
JD560768 - Sequence 541792 from Patent EP1572962.
JD532679 - Sequence 513703 from Patent EP1572962.
JD495977 - Sequence 477001 from Patent EP1572962.
JD080922 - Sequence 61946 from Patent EP1572962.
JD242582 - Sequence 223606 from Patent EP1572962.
JD240681 - Sequence 221705 from Patent EP1572962.
JD318569 - Sequence 299593 from Patent EP1572962.
JD356536 - Sequence 337560 from Patent EP1572962.
JD243682 - Sequence 224706 from Patent EP1572962.
JD242999 - Sequence 224023 from Patent EP1572962.
JD460436 - Sequence 441460 from Patent EP1572962.
JD105160 - Sequence 86184 from Patent EP1572962.
JD151336 - Sequence 132360 from Patent EP1572962.
JD489741 - Sequence 470765 from Patent EP1572962.
JD493954 - Sequence 474978 from Patent EP1572962.
JD448878 - Sequence 429902 from Patent EP1572962.
AK308288 - Homo sapiens cDNA, FLJ98236.
JD300602 - Sequence 281626 from Patent EP1572962.
JD074749 - Sequence 55773 from Patent EP1572962.
JD145645 - Sequence 126669 from Patent EP1572962.
JD443115 - Sequence 424139 from Patent EP1572962.
JD065018 - Sequence 46042 from Patent EP1572962.
JD506714 - Sequence 487738 from Patent EP1572962.
JD290294 - Sequence 271318 from Patent EP1572962.
JD260351 - Sequence 241375 from Patent EP1572962.
AK294791 - Homo sapiens cDNA FLJ60504 complete cds.
JD137309 - Sequence 118333 from Patent EP1572962.
JD273070 - Sequence 254094 from Patent EP1572962.
HQ448013 - Synthetic construct Homo sapiens clone IMAGE:100071386; CCSB010696_02 family with sequence similarity 134, member C (FAM134C) gene, encodes complete protein.
KJ895723 - Synthetic construct Homo sapiens clone ccsbBroadEn_05117 FAM134C gene, encodes complete protein.
L77587 - Homo sapiens (clone SEL101) 17q YAC (176F3) RNA.
L38937 - Homo sapiens GT227 mRNA.
DQ590809 - Homo sapiens piRNA piR-57921, complete sequence.
CU690614 - Synthetic construct Homo sapiens gateway clone IMAGE:100020933 5' read FAM134C mRNA.
DQ592383 - Homo sapiens piRNA piR-59495, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: F134C_HUMAN, FAM134C, NM_178126, NP_835227, Q86VR2
UCSC ID: uc002ial.2
RefSeq Accession: NM_178126
Protein: Q86VR2 (aka F134C_HUMAN)
CCDS: CCDS11432.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_178126.3
exon count: 10CDS single in 3' UTR: no RNA size: 3818
ORF size: 1401CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 2591.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.