Description: Homo sapiens mitochondrial ribosomal protein L24 (MRPL24), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. RefSeq Summary (NM_145729): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:156,707,094-156,710,923 Size: 3,830 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr1:156,707,190-156,708,496 Size: 1,307 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96A35
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK024570 - Homo sapiens cDNA: FLJ20917 fis, clone ADSE00750. AK222500 - Homo sapiens mRNA for mitochondrial ribosomal protein L24 variant, clone: adSE00750. AK223066 - Homo sapiens mRNA for mitochondrial ribosomal protein L24 variant, clone: KAT01811. JD299815 - Sequence 280839 from Patent EP1572962. BC016700 - Homo sapiens mitochondrial ribosomal protein L24, mRNA (cDNA clone MGC:22737 IMAGE:4108596), complete cds. BC012440 - Homo sapiens mitochondrial ribosomal protein L24, mRNA (cDNA clone MGC:9831 IMAGE:3863359), complete cds. JD199421 - Sequence 180445 from Patent EP1572962. JD165074 - Sequence 146098 from Patent EP1572962. JD186289 - Sequence 167313 from Patent EP1572962. JD294895 - Sequence 275919 from Patent EP1572962. CR457329 - Homo sapiens full open reading frame cDNA clone RZPDo834E129D for gene MRPL24, mitochondrial ribosomal protein L24; complete cds, incl. stopcodon. JD455156 - Sequence 436180 from Patent EP1572962. JD143225 - Sequence 124249 from Patent EP1572962. JD396534 - Sequence 377558 from Patent EP1572962. JD270964 - Sequence 251988 from Patent EP1572962. DQ575726 - Homo sapiens piRNA piR-43838, complete sequence. JD144358 - Sequence 125382 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96A35 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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