Human Gene SLC22A10 (uc009yor.3)
  Description: Homo sapiens solute carrier family 22, member 10 (SLC22A10), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:63,057,430-63,079,246 Size: 21,817 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr11:63,057,638-63,078,506 Size: 20,869 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:63,057,430-63,079,246)mRNA (may differ from genome)Protein (541 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S22AA_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 22 member 10; AltName: Full=Organic anion transporter 5;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Detected in fetal and adult liver, and in adult kidney.
SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.77 RPKM in Liver
Total median expression: 7.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.40208-0.218 Picture PostScript Text
3' UTR -133.94740-0.181 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005828 - Sub_transporter

Pfam Domains:
PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q63ZE4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005452 inorganic anion exchanger activity
GO:0015143 urate transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0015698 inorganic anion transport
GO:0015747 urate transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK296299 - Homo sapiens cDNA FLJ60017 complete cds, highly similar to Solute carrier family 22 member 10.
AK298430 - Homo sapiens cDNA FLJ60319 complete cds, highly similar to Solute carrier family 22 member 10.
AB075876 - Homo sapiens mRNA for putative protein product of HMFN2567, complete cds.
BC160176 - Synthetic construct Homo sapiens clone IMAGE:100064208, MGC:193291 solute carrier family 22, member 10 (SLC22A10) mRNA, encodes complete protein.
BC171744 - Homo sapiens cDNA clone IMAGE:9053079.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001039752, NP_001034841, OAT5, Q63ZE4, S22AA_HUMAN
UCSC ID: uc009yor.3
RefSeq Accession: NM_001039752
Protein: Q63ZE4 (aka S22AA_HUMAN)
CCDS: CCDS41661.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001039752.3
exon count: 10CDS single in 3' UTR: no RNA size: 2591
ORF size: 1626CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1787.00frame shift in genome: no % Coverage: 99.34
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 320# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.