Human Gene OIT3 (uc001jte.1)
  Description: Homo sapiens oncoprotein induced transcript 3 (OIT3), mRNA.
RefSeq Summary (NM_152635): This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016].
Transcript (Including UTRs)
   Position: hg19 chr10:74,653,339-74,692,787 Size: 39,449 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr10:74,653,557-74,692,282 Size: 38,726 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:74,653,339-74,692,787)mRNA (may differ from genome)Protein (545 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OIT3_HUMAN
DESCRIPTION: RecName: Full=Oncoprotein-induced transcript 3 protein; AltName: Full=Liver-specific zona pellucida domain-containing protein; Flags: Precursor;
FUNCTION: May be involved in hepatocellular function and development.
SUBCELLULAR LOCATION: Nucleus envelope. Note=Can be secreted into blood.
TISSUE SPECIFICITY: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.
SIMILARITY: Contains 1 EGF-like domain.
SIMILARITY: Contains 1 ZP domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: OIT3
Diseases sorted by gene-association score: familial juvenile hyperuricaemic nephropathy (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.46 RPKM in Liver
Total median expression: 19.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -66.10218-0.303 Picture PostScript Text
3' UTR -122.47505-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd
IPR000152 - EGF-type_Asp/Asn_hydroxyl_site
IPR018097 - EGF_Ca-bd_CS
IPR001507 - ZP_dom

Pfam Domains:
PF00100 - Zona pellucida-like domain
PF14670 - Coagulation Factor Xa inhibitory site

SCOP Domains:
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on Q8WWZ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding

Biological Process:
GO:1903118 urate homeostasis

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope


-  Descriptions from all associated GenBank mRNAs
  AK096435 - Homo sapiens cDNA FLJ39116 fis, clone NTONG2006301, highly similar to Mus musculus EF-9 mRNA.
BC126440 - Homo sapiens oncoprotein induced transcript 3, mRNA (cDNA clone MGC:161718 IMAGE:8992156), complete cds.
JD418907 - Sequence 399931 from Patent EP1572962.
AY358339 - Homo sapiens clone DNA68883 PPFL826 (UNQ826) mRNA, complete cds.
JD253807 - Sequence 234831 from Patent EP1572962.
JD131992 - Sequence 113016 from Patent EP1572962.
JD181717 - Sequence 162741 from Patent EP1572962.
AY013707 - Homo sapiens LZP (LZP) mRNA, complete cds.
JD043826 - Sequence 24850 from Patent EP1572962.
JD044604 - Sequence 25628 from Patent EP1572962.
HQ258178 - Synthetic construct Homo sapiens clone IMAGE:100072487 Unknown protein gene, encodes complete protein.
KJ903964 - Synthetic construct Homo sapiens clone ccsbBroadEn_13358 OIT3 gene, encodes complete protein.
AF075085 - Homo sapiens full length insert cDNA YQ83G05.
JD257427 - Sequence 238451 from Patent EP1572962.
JD258073 - Sequence 239097 from Patent EP1572962.
JD372017 - Sequence 353041 from Patent EP1572962.
JD072509 - Sequence 53533 from Patent EP1572962.
JD220936 - Sequence 201960 from Patent EP1572962.
JD496229 - Sequence 477253 from Patent EP1572962.
JD367868 - Sequence 348892 from Patent EP1572962.
JD363554 - Sequence 344578 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVP3, LZP, NM_152635, NP_689848, OIT3_HUMAN, Q8N1M8, Q8WWZ8, UNQ826/PRO1753
UCSC ID: uc001jte.1
RefSeq Accession: NM_152635
Protein: Q8WWZ8 (aka OIT3_HUMAN)
CCDS: CCDS7318.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152635.1
exon count: 9CDS single in 3' UTR: no RNA size: 2361
ORF size: 1638CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 3476.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.