Description: Homo sapiens calicin (CCIN), mRNA. RefSeq Summary (NM_005893): The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr9:36,169,389-36,171,331 Size: 1,943 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr9:36,169,500-36,171,266 Size: 1,767 Coding Exon Count: 1
ID:CALI_HUMAN DESCRIPTION: RecName: Full=Calicin; FUNCTION: Possible morphogenetic cytoskeletal element in spermiogenic differentiation. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus. TISSUE SPECIFICITY: Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 Kelch repeats.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CCIN CDC HuGE Published Literature: CCIN Positive Disease Associations: smoking cessation Related Studies:
smoking cessation Uhl ,et al. Pharmacogenomics 2010, Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement , Pharmacogenomics 2010 11- 3 : 357-67.
[PubMed 20235792]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13939
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
