Description: Homo sapiens Charcot-Leyden crystal protein (CLC), mRNA. RefSeq Summary (NM_001828): Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:40,221,893-40,228,669 Size: 6,777 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr19:40,222,020-40,228,592 Size: 6,573 Coding Exon Count: 4
ID:LPPL_HUMAN DESCRIPTION: RecName: Full=Eosinophil lysophospholipase; EC=3.1.1.5; AltName: Full=Charcot-Leyden crystal protein; Short=CLC; AltName: Full=Galectin-10; Short=Gal-10; AltName: Full=Lysolecithin acylhydrolase; FUNCTION: May have both lysophospholipase and carbohydrate-binding activities. CATALYTIC ACTIVITY: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell. TISSUE SPECIFICITY: Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. MISCELLANEOUS: Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias. SIMILARITY: Contains 1 galectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-10; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_277";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q05315
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0030246 carbohydrate binding GO:0042802 identical protein binding GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process GO:0004622 lysophospholipase activity
Biological Process: GO:0002667 regulation of T cell anergy GO:0002724 regulation of T cell cytokine production GO:0007275 multicellular organism development GO:0046006 regulation of activated T cell proliferation GO:0070231 T cell apoptotic process
US Server
