Human Gene DDIT3 (uc021qzk.1) Description and Page Index
Description: Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), transcript variant 3, mRNA. RefSeq Summary (NM_001195055): This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]. Transcript (Including UTRs) Position: hg19 chr12:57,910,371-57,914,300 Size: 3,930 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr12:57,910,592-57,911,258 Size: 667 Coding Exon Count: 2
ID:F8VS99_HUMAN DESCRIPTION: SubName: Full=DNA damage-inducible transcript 3 protein; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DDIT3 CDC HuGE Published Literature: DDIT3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07716 - Basic region leucine zipper
ModBase Predicted Comparative 3D Structure on F8VS99
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.