Human Gene DDIT3 (uc021qzk.1) Description and Page Index
  Description: Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), transcript variant 3, mRNA.
RefSeq Summary (NM_001195055): This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010].
Transcript (Including UTRs)
   Position: hg19 chr12:57,910,371-57,914,300 Size: 3,930 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr12:57,910,592-57,911,258 Size: 667 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:57,910,371-57,914,300)mRNA (may differ from genome)Protein (192 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=DNA damage-inducible transcript 3 protein;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DDIT3
CDC HuGE Published Literature: DDIT3

-  MalaCards Disease Associations
  MalaCards Gene Search: DDIT3
Diseases sorted by gene-association score: myxoid liposarcoma* (439), liposarcoma (18), liposarcoma of the ovary (5), myxoid liposarcoma of the ovary (5), fatty liver disease (5), ewing sarcoma (3), colorectal cancer (2), ovary sarcoma (2), atypical lipomatous tumor (1), mixed liposarcoma (1), chondroid lipoma (1), cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (1), chondrosarcoma, extraskeletal myxoid (1), spindle cell liposarcoma (1), spinocerebellar ataxia 14 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 39.62 RPKM in Thyroid
Total median expression: 1068.05 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.70192-0.280 Picture PostScript Text
3' UTR -55.82221-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR016670 - DNA_damage_induc_transcript_3

Pfam Domains:
PF07716 - Basic region leucine zipper

ModBase Predicted Comparative 3D Structure on F8VS99
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  LF208930 - JP 2014500723-A/16433: Polycomb-Associated Non-Coding RNAs.
LF385493 - JP 2014500723-A/192996: Polycomb-Associated Non-Coding RNAs.
AY461580 - Homo sapiens BRL protein-like mRNA, complete sequence.
BC064556 - Homo sapiens DNA-damage-inducible transcript 3, mRNA (cDNA clone IMAGE:5550187), with apparent retained intron.
X71427 - Homo sapiens mRNA for FUS-CHOP protein fusion.
BC003637 - Homo sapiens DNA-damage-inducible transcript 3, mRNA (cDNA clone MGC:4154 IMAGE:3530545), complete cds.
S40706 - Homo sapiens Gadd153 (GADD153) mRNA, complete cds.
JD045253 - Sequence 26277 from Patent EP1572962.
X92120 - H.sapiens EWS/CHOP chimeric fragment.
EU831488 - Synthetic construct Homo sapiens clone HAIB:100066517; DKFZo008H0617 DNA-damage-inducible transcript 3 protein (DDIT3) gene, encodes complete protein.
AK316581 - Homo sapiens cDNA, FLJ94723, Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), mRNA.
EU831575 - Synthetic construct Homo sapiens clone HAIB:100066604; DKFZo004H0618 DNA-damage-inducible transcript 3 protein (DDIT3) gene, encodes complete protein.
KJ896695 - Synthetic construct Homo sapiens clone ccsbBroadEn_06089 DDIT3 gene, encodes complete protein.
BT006691 - Homo sapiens DNA-damage-inducible transcript 3 mRNA, complete cds.
AB587582 - Synthetic construct DNA, clone: pF1KB8878, Homo sapiens DDIT3 gene for DNA-damage-inducible transcript 3, without stop codon, in Flexi system.
CU678550 - Synthetic construct Homo sapiens gateway clone IMAGE:100020178 5' read DDIT3 mRNA.
LF324171 - JP 2014500723-A/131674: Polycomb-Associated Non-Coding RNAs.
LF324170 - JP 2014500723-A/131673: Polycomb-Associated Non-Coding RNAs.
LF324167 - JP 2014500723-A/131670: Polycomb-Associated Non-Coding RNAs.
LF324166 - JP 2014500723-A/131669: Polycomb-Associated Non-Coding RNAs.
AJ301612 - Homo sapiens partial mRNA for FUS/CHOP chimaeric fusion protein (type 9 transcript variant).
JD086844 - Sequence 67868 from Patent EP1572962.
JD437319 - Sequence 418343 from Patent EP1572962.
BC107859 - Homo sapiens cDNA clone IMAGE:4687818.
LF324161 - JP 2014500723-A/131664: Polycomb-Associated Non-Coding RNAs.
JD064943 - Sequence 45967 from Patent EP1572962.
JD071556 - Sequence 52580 from Patent EP1572962.
JD532551 - Sequence 513575 from Patent EP1572962.
MA621070 - JP 2018138019-A/192996: Polycomb-Associated Non-Coding RNAs.
MA559748 - JP 2018138019-A/131674: Polycomb-Associated Non-Coding RNAs.
MA559747 - JP 2018138019-A/131673: Polycomb-Associated Non-Coding RNAs.
MA559744 - JP 2018138019-A/131670: Polycomb-Associated Non-Coding RNAs.
MA559743 - JP 2018138019-A/131669: Polycomb-Associated Non-Coding RNAs.
MA559738 - JP 2018138019-A/131664: Polycomb-Associated Non-Coding RNAs.
MA444507 - JP 2018138019-A/16433: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_p38mapkPathway - p38 MAPK Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: F8VS99, F8VS99_HUMAN, NM_001195055, NP_004074
UCSC ID: uc021qzk.1
RefSeq Accession: NM_001195055
Protein: F8VS99 CCDS: CCDS55838.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001195055.1
exon count: 4CDS single in 3' UTR: no RNA size: 1005
ORF size: 579CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1253.00frame shift in genome: no % Coverage: 98.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.