Human Gene ZNF662 (uc003cmk.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 662 (ZNF662), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:42,947,658-42,960,825 Size: 13,168 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr3:42,947,844-42,956,846 Size: 9,003 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:42,947,658-42,960,825)mRNA (may differ from genome)Protein (452 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Zinc finger protein 662;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF662
CDC HuGE Published Literature: ZNF662
Positive Disease Associations: Sleep
Related Studies:
  1. Sleep
    Daniel J Gottlieb et al. BMC medical genetics 2007, Genome-wide association of sleep and circadian phenotypes., BMC medical genetics. [PubMed 17903308]
    This analysis confirms prior reports of significant heritability of sleepiness, usual bedtime, and usual sleep duration. Several genetic loci with suggestive linkage to these traits are identified, including linkage peaks containing circadian clock-related genes. Association tests identify NPSR1 and PDE4D as possible mediators of bedtime and sleepiness.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.25 RPKM in Ovary
Total median expression: 159.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.40186-0.481 Picture PostScript Text
3' UTR -1347.083979-0.339 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on F8W7S8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Descriptions from all associated GenBank mRNAs
  AK127779 - Homo sapiens cDNA FLJ45880 fis, clone OCBBF3020263, moderately similar to Zinc finger protein 135.
AK128676 - Homo sapiens cDNA FLJ46840 fis, clone UTERU2037423, moderately similar to Zinc finger protein 135.
JD484181 - Sequence 465205 from Patent EP1572962.
JD462951 - Sequence 443975 from Patent EP1572962.
JD520728 - Sequence 501752 from Patent EP1572962.
BC128085 - Homo sapiens zinc finger protein 662, mRNA (cDNA clone MGC:149141 IMAGE:40108370), complete cds.
JD136010 - Sequence 117034 from Patent EP1572962.
KJ904256 - Synthetic construct Homo sapiens clone ccsbBroadEn_13650 ZNF662 gene, encodes complete protein.
AK131235 - Homo sapiens cDNA FLJ16145 fis, clone BRAMY2039341, moderately similar to ZINC FINGER PROTEIN 135.
JD032199 - Sequence 13223 from Patent EP1572962.
AK054699 - Homo sapiens cDNA FLJ30137 fis, clone BRACE2000078.
AK090754 - Homo sapiens cDNA FLJ33435 fis, clone BRACE2021344.
AK090666 - Homo sapiens cDNA FLJ33347 fis, clone BRACE2003873.
JD454132 - Sequence 435156 from Patent EP1572962.
JD376139 - Sequence 357163 from Patent EP1572962.
JD376140 - Sequence 357164 from Patent EP1572962.
JD246984 - Sequence 228008 from Patent EP1572962.
JD246985 - Sequence 228009 from Patent EP1572962.
JD413425 - Sequence 394449 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: F8W7S8, F8W7S8_HUMAN, NM_001134656, NP_001128128
UCSC ID: uc003cmk.2
RefSeq Accession: NM_001134656
Protein: F8W7S8 CCDS: CCDS46807.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001134656.1
exon count: 4CDS single in 3' UTR: no RNA size: 5524
ORF size: 1359CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2918.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.