ID:F8W7S8_HUMAN DESCRIPTION: SubName: Full=Zinc finger protein 662; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ZNF662 CDC HuGE Published Literature: ZNF662 Positive Disease Associations: Sleep Related Studies:
Sleep Daniel J Gottlieb et al. BMC medical genetics 2007, Genome-wide association of sleep and circadian phenotypes., BMC medical genetics.
This analysis confirms prior reports of significant heritability of sleepiness, usual bedtime, and usual sleep duration. Several genetic loci with suggestive linkage to these traits are identified, including linkage peaks containing circadian clock-related genes. Association tests identify NPSR1 and PDE4D as possible mediators of bedtime and sleepiness.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F8W7S8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK127779 - Homo sapiens cDNA FLJ45880 fis, clone OCBBF3020263, moderately similar to Zinc finger protein 135. AK128676 - Homo sapiens cDNA FLJ46840 fis, clone UTERU2037423, moderately similar to Zinc finger protein 135. JD484181 - Sequence 465205 from Patent EP1572962. JD462951 - Sequence 443975 from Patent EP1572962. JD520728 - Sequence 501752 from Patent EP1572962. BC128085 - Homo sapiens zinc finger protein 662, mRNA (cDNA clone MGC:149141 IMAGE:40108370), complete cds. JD136010 - Sequence 117034 from Patent EP1572962. KJ904256 - Synthetic construct Homo sapiens clone ccsbBroadEn_13650 ZNF662 gene, encodes complete protein. AK131235 - Homo sapiens cDNA FLJ16145 fis, clone BRAMY2039341, moderately similar to ZINC FINGER PROTEIN 135. JD032199 - Sequence 13223 from Patent EP1572962. AK054699 - Homo sapiens cDNA FLJ30137 fis, clone BRACE2000078. AK090754 - Homo sapiens cDNA FLJ33435 fis, clone BRACE2021344. AK090666 - Homo sapiens cDNA FLJ33347 fis, clone BRACE2003873. JD454132 - Sequence 435156 from Patent EP1572962. JD376139 - Sequence 357163 from Patent EP1572962. JD376140 - Sequence 357164 from Patent EP1572962. JD246984 - Sequence 228008 from Patent EP1572962. JD246985 - Sequence 228009 from Patent EP1572962. JD413425 - Sequence 394449 from Patent EP1572962.