Human Gene LECT2 (uc003lbe.1) Description and Page Index
Description: Homo sapiens leukocyte cell-derived chemotaxin 2 (LECT2), mRNA. RefSeq Summary (NM_002302): This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D63521.1, SRR5189664.25165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000274507.6/ ENSP00000274507.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr5:135,282,600-135,290,723 Size: 8,124 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr5:135,283,020-135,290,522 Size: 7,503 Coding Exon Count: 4
ID:LECT2_HUMAN DESCRIPTION: RecName: Full=Leukocyte cell-derived chemotaxin-2; Short=LECT-2; Short=hLECT2; Flags: Precursor; FUNCTION: Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. SUBCELLULAR LOCATION: Cytoplasm. Secreted. TISSUE SPECIFICITY: Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow. INDUCTION: By phytohemagglutinin (PHA). SIMILARITY: Belongs to the LECT2/MIM-1 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LECT2 CDC HuGE Published Literature: LECT2 Positive Disease Associations: Magnesium Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14960
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.