Human Gene GBP7 (uc001dna.2) Description and Page Index
Description: Homo sapiens guanylate binding protein 7 (GBP7), mRNA. RefSeq Summary (NM_207398): Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]. Sequence Note: This sequence has been modified as follows: removed 36 bp suspected to be vector contamination from the 3' end. ##Evidence-Data-START## Transcript exon combination :: AK096141.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000294671.3/ ENSP00000294671.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr1:89,597,434-89,641,723 Size: 44,290 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr1:89,597,832-89,637,618 Size: 39,787 Coding Exon Count: 10
ID:GBP7_HUMAN DESCRIPTION: RecName: Full=Guanylate-binding protein 7; AltName: Full=GTP-binding protein 7; Short=GBP-7; AltName: Full=Guanine nucleotide-binding protein 7; AltName: Full=Guanylate-binding protein 4-like; FUNCTION: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). SUBCELLULAR LOCATION: Membrane (Potential). SIMILARITY: Belongs to the GBP family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GBP7 CDC HuGE Published Literature: GBP7 Positive Disease Associations: Cholesterol Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N8V2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary