Human Gene GBP7 (uc001dna.2) Description and Page Index
  Description: Homo sapiens guanylate binding protein 7 (GBP7), mRNA.
RefSeq Summary (NM_207398): Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]. Sequence Note: This sequence has been modified as follows: removed 36 bp suspected to be vector contamination from the 3' end. ##Evidence-Data-START## Transcript exon combination :: AK096141.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000294671.3/ ENSP00000294671.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:89,597,434-89,641,723 Size: 44,290 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr1:89,597,832-89,637,618 Size: 39,787 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:89,597,434-89,641,723)mRNA (may differ from genome)Protein (638 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Guanylate-binding protein 7; AltName: Full=GTP-binding protein 7; Short=GBP-7; AltName: Full=Guanine nucleotide-binding protein 7; AltName: Full=Guanylate-binding protein 4-like;
FUNCTION: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
SUBCELLULAR LOCATION: Membrane (Potential).
SIMILARITY: Belongs to the GBP family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GBP7
CDC HuGE Published Literature: GBP7
Positive Disease Associations: Cholesterol
Related Studies:
  1. Cholesterol
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.50 RPKM in Liver
Total median expression: 18.01 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.56139-0.249 Picture PostScript Text
3' UTR -60.45398-0.152 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003191 - Guanylate-bd_C
IPR015894 - Guanylate-bd_N

Pfam Domains:
PF01442 - Apolipoprotein A1/A4/E domain
PF02263 - Guanylate-binding protein, N-terminal domain
PF02841 - Guanylate-binding protein, C-terminal domain

SCOP Domains:
48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q8N8V2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component:
GO:0016020 membrane

-  Descriptions from all associated GenBank mRNAs
  AL832451 - Homo sapiens mRNA; cDNA DKFZp451C2311 (from clone DKFZp451C2311); complete cds.
AK096141 - Homo sapiens cDNA FLJ38822 fis, clone LIVER2008706, moderately similar to Mus musculus purine nucleotide binding protein mRNA.
BC156123 - Synthetic construct Homo sapiens clone IMAGE:100062387, MGC:190496 guanylate binding protein 7 (GBP7) mRNA, encodes complete protein.
BC157015 - Synthetic construct Homo sapiens clone IMAGE:100062829, MGC:190626 guanylate binding protein 7 (GBP7) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N8V2 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: GBP4L, GBP7_HUMAN, NM_207398, NP_997281, Q8N8V2
UCSC ID: uc001dna.2
RefSeq Accession: NM_207398
Protein: Q8N8V2 (aka GBP7_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_207398.2
exon count: 11CDS single in 3' UTR: no RNA size: 2454
ORF size: 1917CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4034.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.