Description: Homo sapiens sorting and assembly machinery component 50 homolog (S. cerevisiae) (SAMM50), mRNA. RefSeq Summary (NM_015380): This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]. Transcript (Including UTRs) Position: hg19 chr22:44,351,261-44,392,412 Size: 41,152 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr22:44,351,458-44,392,263 Size: 40,806 Coding Exon Count: 15
ID:SAM50_HUMAN DESCRIPTION: RecName: Full=Sorting and assembly machinery component 50 homolog; AltName: Full=Transformation-related gene 3 protein; Short=TRG-3; FUNCTION: May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity). SUBUNIT: Associates with the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3. SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm (By similarity). DOMAIN: Its C-terminal part seems to contain many membrane- spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure (By similarity). SIMILARITY: Belongs to the SAM50/omp85 family.
plasma levels of liver enzymes Yuan ,et al. 2008, Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes, American journal of human genetics 2008 83- 4 : 520-8.
[PubMed 18940312]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y512
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
