Human Gene ASCC2 (uc003agr.3) Description and Page Index
  Description: Homo sapiens activating signal cointegrator 1 complex subunit 2 (ASCC2), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:30,184,597-30,234,293 Size: 49,697 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr22:30,185,002-30,228,314 Size: 43,313 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:30,184,597-30,234,293)mRNA (may differ from genome)Protein (757 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ASCC2_HUMAN
DESCRIPTION: RecName: Full=Activating signal cointegrator 1 complex subunit 2; AltName: Full=ASC-1 complex subunit p100; AltName: Full=Trip4 complex subunit p100;
FUNCTION: Enhances NF-kappa-B, SRF and AP1 transactivation.
SUBUNIT: Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the ASCC2 family.
SIMILARITY: Contains 1 CUE domain.
SEQUENCE CAUTION: Sequence=BAB15089.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.13 RPKM in Whole Blood
Total median expression: 741.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.50144-0.469 Picture PostScript Text
3' UTR -136.46405-0.337 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003892 - CUE
IPR009060 - UBA-like

Pfam Domains:
PF02845 - CUE domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DI0
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9H1I8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006307 DNA dealkylation involved in DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0099053 activating signal cointegrator 1 complex


-  Descriptions from all associated GenBank mRNAs
  BC032760 - Homo sapiens activating signal cointegrator 1 complex subunit 2, mRNA (cDNA clone IMAGE:3452507), with apparent retained intron.
AL096741 - Homo sapiens mRNA; cDNA DKFZp586O0223 (from clone DKFZp586O0223).
AK025241 - Homo sapiens cDNA: FLJ21588 fis, clone COL06949.
AK222723 - Homo sapiens mRNA for activating signal cointegrator 1 complex subunit 2 variant, clone: COL06949.
AK223033 - Homo sapiens mRNA for activating signal cointegrator 1 complex subunit 2 variant, clone: HUV01010.
BC025368 - Homo sapiens activating signal cointegrator 1 complex subunit 2, mRNA (cDNA clone MGC:15020 IMAGE:3955747), complete cds.
AY013289 - Homo sapiens ASC-1 complex subunit P100 mRNA, complete cds.
AK022886 - Homo sapiens cDNA FLJ12824 fis, clone NT2RP2002753.
JD285869 - Sequence 266893 from Patent EP1572962.
JD049514 - Sequence 30538 from Patent EP1572962.
JD176222 - Sequence 157246 from Patent EP1572962.
JD064497 - Sequence 45521 from Patent EP1572962.
JD197270 - Sequence 178294 from Patent EP1572962.
JD255013 - Sequence 236037 from Patent EP1572962.
JD088235 - Sequence 69259 from Patent EP1572962.
JD319163 - Sequence 300187 from Patent EP1572962.
AK303257 - Homo sapiens cDNA FLJ53441 complete cds, highly similar to Activating signal cointegrator 1 complex subunit 2.
JD451613 - Sequence 432637 from Patent EP1572962.
KJ894943 - Synthetic construct Homo sapiens clone ccsbBroadEn_04337 ASCC2 gene, encodes complete protein.
AB590901 - Synthetic construct DNA, clone: pFN21AE2083, Homo sapiens ASCC2 gene for activating signal cointegrator 1 complex subunit 2, without stop codon, in Flexi system.
JD141330 - Sequence 122354 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H1I8 (Reactome details) participates in the following event(s):

R-HSA-5657617 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC
R-HSA-5657637 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA
R-HSA-5657642 ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA
R-HSA-112123 Oxidative demethylation of 1-meA damaged DNA By ALKBH3
R-HSA-112124 Oxidative demethylation of 3-meC damaged DNA By ALKBH3
R-HSA-112125 Oxidative dealkylation of 1-EtA damaged DNA by ABH3
R-HSA-112126 ALKBH3 mediated reversal of alkylation damage
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases
R-HSA-73942 DNA Damage Reversal
R-HSA-73894 DNA Repair

-  Other Names for This Gene
  Alternate Gene Symbols: ASC1P100, ASCC2_HUMAN, NM_032204, NP_115580, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6
UCSC ID: uc003agr.3
RefSeq Accession: NM_032204
Protein: Q9H1I8 (aka ASCC2_HUMAN or ACC2_HUMAN)
CCDS: CCDS13869.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032204.4
exon count: 20CDS single in 3' UTR: no RNA size: 2840
ORF size: 2274CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4733.00frame shift in genome: no % Coverage: 99.40
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.