Human Gene TOX4 (uc001waz.3) Description and Page Index
Description: Homo sapiens TOX high mobility group box family member 4 (TOX4), mRNA.
Transcript (Including UTRs)
Position: hg19 chr14:21,945,335-21,967,319 Size: 21,985 Total Exon Count: 9 Strand: +
Position: hg19 chr14:21,945,438-21,964,764 Size: 19,327 Coding Exon Count: 9
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=TOX high mobility group box family member 4; AltName: Full=Epidermal Langerhans cell protein LCP1;
FUNCTION: Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. SUBUNIT: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS. SUBCELLULAR LOCATION: Nucleus (Probable). Note=Associated with chromatin. SIMILARITY: Contains 1 HMG box DNA-binding domain. SEQUENCE CAUTION: Sequence=BAA34457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR009071 - HMG_superfamily
Pfam Domains: PF00505 - HMG (high mobility group) box
PF09011 - HMG-box domain
SCOP Domains: 47095 - HMG-box
ModBase Predicted Comparative 3D Structure on O94842
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC035050 - Homo sapiens TOX high mobility group box family member 4, mRNA (cDNA clone IMAGE:5266241), with apparent retained intron. AK295913 - Homo sapiens cDNA FLJ54357 complete cds, highly similar to Epidermal Langerhans cell protein LCP1. AK299807 - Homo sapiens cDNA FLJ54382 complete cds, highly similar to Epidermal Langerhans cell protein LCP1. BC020727 - Homo sapiens TOX high mobility group box family member 4, mRNA (cDNA clone IMAGE:4721305). AK298555 - Homo sapiens cDNA FLJ54372 complete cds, highly similar to Epidermal Langerhans cell protein LCP1. BC013689 - Homo sapiens TOX high mobility group box family member 4, mRNA (cDNA clone MGC:9406 IMAGE:3880134), complete cds. BC020292 - Homo sapiens TOX high mobility group box family member 4, mRNA (cDNA clone IMAGE:3464161). AB018280 - Homo sapiens KIAA0737 mRNA for KIAA0737 protein. CU680652 - Synthetic construct Homo sapiens gateway clone IMAGE:100020788 5' read TOX4 mRNA. AB385378 - Synthetic construct DNA, clone: pF1KA0737, Homo sapiens TOX4 gene for TOX high mobility group box family member 4, complete cds, without stop codon, in Flexi system. EU446865 - Synthetic construct Homo sapiens clone IMAGE:100070261; IMAGE:100012074; FLH258197.01L TOX high mobility group box family member 4 (TOX4) gene, encodes complete protein. EU831791 - Synthetic construct Homo sapiens clone HAIB:100066820; DKFZo008D1121 TOX high mobility group box family member 4 protein (TOX4) gene, encodes complete protein. EU831869 - Synthetic construct Homo sapiens clone HAIB:100066898; DKFZo004D1122 TOX high mobility group box family member 4 protein (TOX4) gene, encodes complete protein. KJ898107 - Synthetic construct Homo sapiens clone ccsbBroadEn_07501 TOX4 gene, encodes complete protein. AK022060 - Homo sapiens cDNA FLJ11998 fis, clone HEMBB1001521. JD156131 - Sequence 137155 from Patent EP1572962. JD070367 - Sequence 51391 from Patent EP1572962. JD118863 - Sequence 99887 from Patent EP1572962. JD347431 - Sequence 328455 from Patent EP1572962. JD546919 - Sequence 527943 from Patent EP1572962. JD511253 - Sequence 492277 from Patent EP1572962. AY305872 - Homo sapiens migration-inducing protein 7 (MIG7) mRNA, complete cds. JD176294 - Sequence 157318 from Patent EP1572962. JD305750 - Sequence 286774 from Patent EP1572962. JD532426 - Sequence 513450 from Patent EP1572962. JD202641 - Sequence 183665 from Patent EP1572962. JD137403 - Sequence 118427 from Patent EP1572962. JD181347 - Sequence 162371 from Patent EP1572962. JD321561 - Sequence 302585 from Patent EP1572962. JD131750 - Sequence 112774 from Patent EP1572962. JD414452 - Sequence 395476 from Patent EP1572962. JD371234 - Sequence 352258 from Patent EP1572962. JD337512 - Sequence 318536 from Patent EP1572962. JD207629 - Sequence 188653 from Patent EP1572962. JD356263 - Sequence 337287 from Patent EP1572962. JD101222 - Sequence 82246 from Patent EP1572962. JD457716 - Sequence 438740 from Patent EP1572962. JD122292 - Sequence 103316 from Patent EP1572962. JD080102 - Sequence 61126 from Patent EP1572962. JD228093 - Sequence 209117 from Patent EP1572962. JD557596 - Sequence 538620 from Patent EP1572962. JD308269 - Sequence 289293 from Patent EP1572962. JD425841 - Sequence 406865 from Patent EP1572962. JD213647 - Sequence 194671 from Patent EP1572962. JD554452 - Sequence 535476 from Patent EP1572962. JD379622 - Sequence 360646 from Patent EP1572962. JD379623 - Sequence 360647 from Patent EP1572962. JD238932 - Sequence 219956 from Patent EP1572962. JD374436 - Sequence 355460 from Patent EP1572962. JD442214 - Sequence 423238 from Patent EP1572962. JD040777 - Sequence 21801 from Patent EP1572962. JD206851 - Sequence 187875 from Patent EP1572962. JD102394 - Sequence 83418 from Patent EP1572962. JD301427 - Sequence 282451 from Patent EP1572962. JD098116 - Sequence 79140 from Patent EP1572962. JD559123 - Sequence 540147 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: C14orf92, KIAA0737, NM_014828, NP_055643, O94842, TOX4_HUMAN UCSC ID: uc001waz.3 RefSeq Accession: NM_014828
(aka TOX4_HUMAN) O94842
Gene Model Information
9 CDS single in 3' UTR:
1866 CDS single in intron:
Alignment % ID:
3920.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.