ID:LCE5A_HUMAN DESCRIPTION: RecName: Full=Late cornified envelope protein 5A; AltName: Full=Late envelope protein 18; AltName: Full=Small proline-rich-like epidermal differentiation complex protein 5A; FUNCTION: Precursors of the cornified envelope of the stratum corneum. TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. Expression is observed in the heart. MISCELLANEOUS: Belongs to the LCE cluster present on 1q21. SIMILARITY: Belongs to the LCE family.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LCE5A CDC HuGE Published Literature: LCE5A Positive Disease Associations: hair morphology Related Studies:
hair morphology Medland ,et al. 2009, Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans, American journal of human genetics 2009 85- 5 : 750-5.
[PubMed 19896111]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TCM9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary