Description: Homo sapiens zinc finger protein 408 (ZNF408), transcript variant 2, mRNA. RefSeq Summary (NM_001184751): The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP). [provided by RefSeq, Dec 2016]. Transcript (Including UTRs) Position: hg19 chr11:46,722,644-46,727,466 Size: 4,823 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr11:46,722,664-46,727,413 Size: 4,750 Coding Exon Count: 5
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ZNF408 CDC HuGE Published Literature: ZNF408 Positive Disease Associations: Bone Density Related Studies:
Bone Density Fernando Rivadeneira et al. Nature genetics 2009, Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies., Nature genetics.
[PubMed 19801982]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DXY4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
