Description: Homo sapiens zinc finger protein 383 (ZNF383), mRNA. RefSeq Summary (NM_152604): The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]. Transcript (Including UTRs) Position: hg19 chr19:37,717,366-37,734,574 Size: 17,209 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr19:37,721,356-37,734,566 Size: 13,211 Coding Exon Count: 4
ID:ZN383_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 383; FUNCTION: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions. TISSUE SPECIFICITY: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle. DEVELOPMENTAL STAGE: In tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lower expression levels in kidney, intestines and prostate. DOMAIN: The KRAB domain is responsible for the transcriptional repressor activity. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 11 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NA42
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter
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