Description: Homo sapiens E2F transcription factor 5, p130-binding (E2F5), transcript variant 1, mRNA. RefSeq Summary (NM_001951): The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:86,089,619-86,126,753 Size: 37,135 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr8:86,089,656-86,126,097 Size: 36,442 Coding Exon Count: 8
ID:E2F5_HUMAN DESCRIPTION: RecName: Full=Transcription factor E2F5; Short=E2F-5; FUNCTION: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. SUBUNIT: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the E2F/DP family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/e2f5/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15329
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U15642 - Human transcription factor E2F-5 mRNA, complete cds. U31556 - Human transcription factor E2F-5 mRNA, complete cds. Z78409 - H.sapiens mRNA for transcription factor E2F5. X86097 - H.sapiens mRNA for E2F-5 protein. AB590542 - Synthetic construct DNA, clone: pFN21AB7924, Homo sapiens E2F5 gene for E2F transcription factor 5, p130-binding, without stop codon, in Flexi system. BC156210 - Synthetic construct Homo sapiens clone IMAGE:100061600, MGC:190047 E2F transcription factor 5, p130-binding (E2F5) mRNA, encodes complete protein. BC172475 - Synthetic construct Homo sapiens clone IMAGE:100069169, MGC:199180 E2F transcription factor 5, p130-binding (E2F5) mRNA, encodes complete protein. AB209185 - Homo sapiens mRNA for Transcription factor E2F5 variant protein. JD550062 - Sequence 531086 from Patent EP1572962. JD359674 - Sequence 340698 from Patent EP1572962. JD524123 - Sequence 505147 from Patent EP1572962. JD495114 - Sequence 476138 from Patent EP1572962. JD265544 - Sequence 246568 from Patent EP1572962. JD269344 - Sequence 250368 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04110 - Cell cycle hsa04350 - TGF-beta signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein Q15329 (Reactome details) participates in the following event(s):
R-HSA-1226094 Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex R-HSA-1227670 Recruitment of HDAC1 by p130 (RBL2) R-HSA-1362261 p130 (RBL2) associates with MuvB to form DREAM complex R-HSA-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 R-HSA-2127257 SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 R-HSA-8964465 DREAM complex binds the PCNA gene promoter R-HSA-8964471 DREAM complex binds the CDC25A gene promoter R-HSA-8964475 DREAM complex binds the TOP2A gene promoter R-HSA-8964482 DREAM complex binds the E2F1 gene promoter R-HSA-8964492 DREAM complex binds the RBL1 gene promoter R-HSA-8964498 DREAM complex binds the CDC6 gene promoter R-HSA-8964550 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter R-HSA-8964561 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter R-HSA-8964567 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter R-HSA-8964580 The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter R-HSA-69231 Cyclin D associated events in G1 R-HSA-1538133 G0 and Early G1 R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-69236 G1 Phase R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-453279 Mitotic G1-G1/S phases R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-69278 Cell Cycle (Mitotic) R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-212436 Generic Transcription Pathway R-HSA-1640170 Cell Cycle R-HSA-9006936 Signaling by TGF-beta family members R-HSA-73857 RNA Polymerase II Transcription R-HSA-162582 Signal Transduction R-HSA-74160 Gene expression (Transcription)
US Server
