Human Gene CZIB (uc001cvd.3)
  Description: Homo sapiens chromosome 1 open reading frame 123 (CZIB), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:53,679,772-53,686,289 Size: 6,518 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr1:53,680,331-53,686,247 Size: 5,917 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:53,679,772-53,686,289)mRNA (may differ from genome)Protein (160 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtPubMed
TreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CA123_HUMAN
DESCRIPTION: RecName: Full=UPF0587 protein C1orf123;
SIMILARITY: Belongs to the UPF0587 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.12 RPKM in Artery - Tibial
Total median expression: 1378.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.8042-0.352 Picture PostScript Text
3' UTR -140.46559-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008584 - DUF866_euk

Pfam Domains:
PF05907 - Eukaryotic protein of unknown function (DUF866)

ModBase Predicted Comparative 3D Structure on Q9NWV4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process


-  Descriptions from all associated GenBank mRNAs
  BC010908 - Homo sapiens chromosome 1 open reading frame 123, mRNA (cDNA clone MGC:13430 IMAGE:4093763), complete cds.
AK000587 - Homo sapiens cDNA FLJ20580 fis, clone REC00516.
AK092734 - Homo sapiens cDNA FLJ35415 fis, clone SMINT2000629.
JD467577 - Sequence 448601 from Patent EP1572962.
JD352730 - Sequence 333754 from Patent EP1572962.
JD237242 - Sequence 218266 from Patent EP1572962.
JD530182 - Sequence 511206 from Patent EP1572962.
JD434146 - Sequence 415170 from Patent EP1572962.
JD325245 - Sequence 306269 from Patent EP1572962.
JD021668 - Sequence 2692 from Patent EP1572962.
JD033897 - Sequence 14921 from Patent EP1572962.
JD038518 - Sequence 19542 from Patent EP1572962.
AK094371 - Homo sapiens cDNA FLJ37052 fis, clone BRACE2013806.
JD505037 - Sequence 486061 from Patent EP1572962.
JD068096 - Sequence 49120 from Patent EP1572962.
JD547280 - Sequence 528304 from Patent EP1572962.
HQ448714 - Synthetic construct Homo sapiens clone IMAGE:100072159; CCSB006381_03 chromosome 1 open reading frame 123 (C1orf123) gene, encodes complete protein.
KJ894110 - Synthetic construct Homo sapiens clone ccsbBroadEn_03504 C1orf123 gene, encodes complete protein.
CR457246 - Homo sapiens full open reading frame cDNA clone RZPDo834D079D for gene FLJ20580, hypothetical protein FLJ20580; complete cds, incl. stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: C1orf123, CA123_HUMAN, NM_017887, NP_060357, Q9NWV4
UCSC ID: uc001cvd.3
RefSeq Accession: NM_017887
Protein: Q9NWV4 (aka CA123_HUMAN)
CCDS: CCDS576.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_017887.1
exon count: 8CDS single in 3' UTR: no RNA size: 1118
ORF size: 483CDS single in intron: no Alignment % ID: 99.72
txCdsPredict score: 1166.00frame shift in genome: no % Coverage: 96.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.