Human Gene GON4L (uc001fly.1)
  Description: Homo sapiens gon-4-like (C. elegans) (GON4L), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:155,719,510-155,826,972 Size: 107,463 Total Exon Count: 32 Strand: -
Coding Region
   Position: hg19 chr1:155,720,375-155,823,571 Size: 103,197 Coding Exon Count: 31 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:155,719,510-155,826,972)mRNA (may differ from genome)Protein (2240 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
PubMedTreefamUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GON4L
CDC HuGE Published Literature: GON4L

-  MalaCards Disease Associations
  MalaCards Gene Search: GON4L
Diseases sorted by gene-association score: globe disease (7), endophthalmitis (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.07 RPKM in Nerve - Tibial
Total median expression: 285.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.7049-0.178 Picture PostScript Text
3' UTR -311.20865-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF02671 - Paired amphipathic helix repeat

SCOP Domains:
46689 - Homeodomain-like
47762 - PAH2 domain

ModBase Predicted Comparative 3D Structure on Q3T8J9-3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AM393852 - Synthetic construct Homo sapiens clone IMAGE:100002492 for hypothetical protein (YY1AP1 gene).
LF206170 - JP 2014500723-A/13673: Polycomb-Associated Non-Coding RNAs.
CU678025 - Synthetic construct Homo sapiens gateway clone IMAGE:100017708 3' read MSTO1 mRNA.
AK000210 - Homo sapiens cDNA FLJ20203 fis, clone COLF1334.
AY335490 - Homo sapiens GON4L isoform A (GON4L) mRNA, complete cds, alternatively spliced.
AY335491 - Homo sapiens GON4L isoform C (GON4L) mRNA, complete cds, alternatively spliced.
BC064933 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone IMAGE:6150234), partial cds.
AB046826 - Homo sapiens mRNA for KIAA1606 protein, partial cds.
JD385653 - Sequence 366677 from Patent EP1572962.
LF352137 - JP 2014500723-A/159640: Polycomb-Associated Non-Coding RNAs.
JD188858 - Sequence 169882 from Patent EP1572962.
JD257765 - Sequence 238789 from Patent EP1572962.
JD508680 - Sequence 489704 from Patent EP1572962.
JD209530 - Sequence 190554 from Patent EP1572962.
JD516517 - Sequence 497541 from Patent EP1572962.
AB195687 - Homo sapiens mRNA for YY1AP-related protein1, complete cds.
AB195688 - Homo sapiens mRNA for YY1AP-related protein2, complete cds.
JD436220 - Sequence 417244 from Patent EP1572962.
LF352135 - JP 2014500723-A/159638: Polycomb-Associated Non-Coding RNAs.
JD540345 - Sequence 521369 from Patent EP1572962.
JD280457 - Sequence 261481 from Patent EP1572962.
AY236966 - Homo sapiens FLJ20203-like mRNA sequence.
BC117557 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone IMAGE:6143327), complete cds.
BC036740 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone IMAGE:4397164), partial cds.
AK222851 - Homo sapiens mRNA for Hypothetical protein DKFZp761I241 (Fragment) variant, clone: HEP07963.
AL136565 - Homo sapiens mRNA; cDNA DKFZp761I241 (from clone DKFZp761I241).
AY335492 - Homo sapiens GON4L isoform B (GON4L) mRNA, complete cds, alternatively spliced.
BX537764 - Homo sapiens mRNA; cDNA DKFZp686H0793 (from clone DKFZp686H0793).
BX648043 - Homo sapiens mRNA; cDNA DKFZp686C19183 (from clone DKFZp686C19183).
BX648802 - Homo sapiens mRNA; cDNA DKFZp686A19184 (from clone DKFZp686A19184).
AK022985 - Homo sapiens cDNA FLJ12923 fis, clone NT2RP2004681, weakly similar to NEUROFILAMENT TRIPLET H PROTEIN.
AB232668 - Homo sapiens mRNA for YY1AP-related protein3, complete cds.
BC114629 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone MGC:138817 IMAGE:40082464), complete cds.
BC115703 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone MGC:138818 IMAGE:40082468), complete cds.
AK315191 - Homo sapiens cDNA, FLJ96175.
BC052260 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone IMAGE:6423083), partial cds.
BC071650 - Homo sapiens gon-4-like (C. elegans), mRNA (cDNA clone IMAGE:5404487), partial cds.
JD436211 - Sequence 417235 from Patent EP1572962.
JD167438 - Sequence 148462 from Patent EP1572962.
JD428849 - Sequence 409873 from Patent EP1572962.
JD360986 - Sequence 342010 from Patent EP1572962.
JD039664 - Sequence 20688 from Patent EP1572962.
JD088149 - Sequence 69173 from Patent EP1572962.
JD088148 - Sequence 69172 from Patent EP1572962.
AK026693 - Homo sapiens cDNA: FLJ23040 fis, clone LNG02277.
AK127876 - Homo sapiens cDNA FLJ45981 fis, clone PROST2017578.
JD490753 - Sequence 471777 from Patent EP1572962.
JD509262 - Sequence 490286 from Patent EP1572962.
JD088713 - Sequence 69737 from Patent EP1572962.
AK098734 - Homo sapiens cDNA FLJ25868 fis, clone CBR02068.
DQ590745 - Homo sapiens piRNA piR-57857, complete sequence.
MA587714 - JP 2018138019-A/159640: Polycomb-Associated Non-Coding RNAs.
MA587712 - JP 2018138019-A/159638: Polycomb-Associated Non-Coding RNAs.
MA441747 - JP 2018138019-A/13673: Polycomb-Associated Non-Coding RNAs.
MN308996 - Homo sapiens LNC_000359 lncRNA, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: GON4, KIAA1606, NM_001037533, NP_001032622, Q3T8J9-3
UCSC ID: uc001fly.1
RefSeq Accession: NM_001037533
Protein: Q3T8J9-3, splice isoform of Q3T8J9 CCDS: CCDS44242.1, CCDS60296.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001037533.1
exon count: 32CDS single in 3' UTR: no RNA size: 7637
ORF size: 6723CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 12059.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.