Description: Homo sapiens mitochondrial methionyl-tRNA formyltransferase (MTFMT), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_139242): The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]. Transcript (Including UTRs) Position: hg19 chr15:65,293,850-65,321,977 Size: 28,128 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr15:65,295,400-65,321,951 Size: 26,552 Coding Exon Count: 9
ID:FMT_HUMAN DESCRIPTION: RecName: Full=Methionyl-tRNA formyltransferase, mitochondrial; Short=MtFMT; EC=2.1.2.9; Flags: Precursor; FUNCTION: Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity). CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + L-methionyl- tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). SUBCELLULAR LOCATION: Mitochondrion (By similarity). DOMAIN: Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C- terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction. SIMILARITY: Belongs to the fmt family. SEQUENCE CAUTION: Sequence=AAH16630.2; Type=Erroneous initiation; Sequence=AAH33687.1; Type=Erroneous initiation; Sequence=BAB70984.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96DP5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
