Human Gene GREB1L (uc010xam.2)
  Description: Homo sapiens growth regulation by estrogen in breast cancer-like (GREB1L), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr18:18,822,203-19,102,791 Size: 280,589 Total Exon Count: 33 Strand: +
Coding Region
   Position: hg19 chr18:18,963,480-19,102,782 Size: 139,303 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:18,822,203-19,102,791)mRNA (may differ from genome)Protein (1923 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GRB1L_HUMAN
DESCRIPTION: RecName: Full=GREB1-like protein;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the GREB1 family.
SEQUENCE CAUTION: Sequence=AAI25018.1; Type=Frameshift; Positions=591; Sequence=BAB14666.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAB14666.1; Type=Frameshift; Positions=675; Sequence=BAB21863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB21863.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Spurious priming from an intronic poly-A tract;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GREB1L
Diseases sorted by gene-association score: renal hypodysplasia/aplasia 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.34 RPKM in Fallopian Tube
Total median expression: 38.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -109.20271-0.403 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024840 - GREB1-like

Pfam Domains:
PF15782 - Gene regulated by oestrogen in breast cancer

ModBase Predicted Comparative 3D Structure on Q9C091
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0003231 cardiac ventricle development
GO:0007275 multicellular organism development
GO:0030539 male genitalia development
GO:0060065 uterus development
GO:0060562 epithelial tube morphogenesis
GO:0061205 paramesonephric duct development
GO:0072177 mesonephric duct development

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB051559 - Homo sapiens mRNA for KIAA1772 protein, partial cds.
BC125017 - Homo sapiens KIAA1772, mRNA (cDNA clone IMAGE:40068078), partial cds.
AK309723 - Homo sapiens cDNA, FLJ99764.
AK293321 - Homo sapiens cDNA FLJ53878 complete cds, weakly similar to Homo sapiens GREB1 protein (GREB1), transcript variant a, mRNA.
AK023749 - Homo sapiens cDNA FLJ13687 fis, clone PLACE2000061.
JD088948 - Sequence 69972 from Patent EP1572962.
JD549079 - Sequence 530103 from Patent EP1572962.
JD513705 - Sequence 494729 from Patent EP1572962.
JD388304 - Sequence 369328 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4QN17, C18orf6, GRB1L_HUMAN, KIAA1772, NM_001142966, NP_001136438, Q9C091, Q9H8F1
UCSC ID: uc010xam.2
RefSeq Accession: NM_001142966
Protein: Q9C091 (aka GRB1L_HUMAN)
CCDS: CCDS45836.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001142966.1
exon count: 33CDS single in 3' UTR: no RNA size: 6052
ORF size: 5772CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 11698.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.