Description: Homo sapiens ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1), transcript variant 3, mRNA. RefSeq Summary (NM_005177): This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:40,672,353-40,674,597 Size: 2,245 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr17:40,672,406-40,673,148 Size: 743 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BD062201 - Gene diagnostic agent/gene therapeutic agent of tumor using tumor specific antigen and novel application of proton pump inhibitor as antitumor drug. L78933 - Homo sapiens vacuolar-type H(+)-ATPase mRNA, complete cds. Z71460 - Homo sapiens mRNA for vacuolar-type H(+)-ATPase 115 kDa subunit. AK223554 - Homo sapiens mRNA for ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 variant, clone: FCC126F11. AK299784 - Homo sapiens cDNA FLJ54439 complete cds, highly similar to Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1. AK316305 - Homo sapiens cDNA, FLJ79204 complete cds, highly similar to Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1. BX648978 - Homo sapiens mRNA; cDNA DKFZp686N0561 (from clone DKFZp686N0561). AK294512 - Homo sapiens cDNA FLJ53780 complete cds, highly similar to Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1. CR627443 - Homo sapiens mRNA; cDNA DKFZp781J1951 (from clone DKFZp781J1951). BC032398 - Homo sapiens ATPase, H+ transporting, lysosomal V0 subunit a1, mRNA (cDNA clone MGC:40328 IMAGE:5195776), complete cds. AK295682 - Homo sapiens cDNA FLJ54433 complete cds, highly similar to Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1. KJ890746 - Synthetic construct Homo sapiens clone ccsbBroadEn_00140 ATP6V0A1 gene, encodes complete protein. AK294789 - Homo sapiens cDNA FLJ53786 complete cds, highly similar to Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1. AL137683 - Homo sapiens mRNA; cDNA DKFZp434H202 (from clone DKFZp434H202); partial cds. AK125927 - Homo sapiens cDNA FLJ43939 fis, clone TESTI4014159. AK098213 - Homo sapiens cDNA FLJ40894 fis, clone UTERU2002001. JD538608 - Sequence 519632 from Patent EP1572962. JD375670 - Sequence 356694 from Patent EP1572962. JD372080 - Sequence 353104 from Patent EP1572962. JD261081 - Sequence 242105 from Patent EP1572962. JD234831 - Sequence 215855 from Patent EP1572962. JD171342 - Sequence 152366 from Patent EP1572962. JD324596 - Sequence 305620 from Patent EP1572962. JD151231 - Sequence 132255 from Patent EP1572962. JD455722 - Sequence 436746 from Patent EP1572962. JD156662 - Sequence 137686 from Patent EP1572962. AL096733 - Homo sapiens mRNA; cDNA DKFZp434E071 (from clone DKFZp434E071). JD564736 - Sequence 545760 from Patent EP1572962. JD112684 - Sequence 93708 from Patent EP1572962. JD274291 - Sequence 255315 from Patent EP1572962. JD088503 - Sequence 69527 from Patent EP1572962. JD161124 - Sequence 142148 from Patent EP1572962. JD487251 - Sequence 468275 from Patent EP1572962. U18920 - Human chromosome 17q12-21 mRNA, clone pOV-3, partial cds. JD206650 - Sequence 187674 from Patent EP1572962. JD051109 - Sequence 32133 from Patent EP1572962. JD260180 - Sequence 241204 from Patent EP1572962. JD324940 - Sequence 305964 from Patent EP1572962. JD418425 - Sequence 399449 from Patent EP1572962. JD201662 - Sequence 182686 from Patent EP1572962. JD403067 - Sequence 384091 from Patent EP1572962. JD392492 - Sequence 373516 from Patent EP1572962. JD060770 - Sequence 41794 from Patent EP1572962. JD544523 - Sequence 525547 from Patent EP1572962. JD219646 - Sequence 200670 from Patent EP1572962. JD536999 - Sequence 518023 from Patent EP1572962. JD535499 - Sequence 516523 from Patent EP1572962. JD390345 - Sequence 371369 from Patent EP1572962. JD190793 - Sequence 171817 from Patent EP1572962. JD218995 - Sequence 200019 from Patent EP1572962. JD252964 - Sequence 233988 from Patent EP1572962. JD042924 - Sequence 23948 from Patent EP1572962. JD443275 - Sequence 424299 from Patent EP1572962. JD253587 - Sequence 234611 from Patent EP1572962. JD466109 - Sequence 447133 from Patent EP1572962. JD272795 - Sequence 253819 from Patent EP1572962.