Description: Homo sapiens ADP-ribosylation factor-like 14 effector protein (ARL14EP), mRNA. RefSeq Summary (NM_152316): The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]. Transcript (Including UTRs) Position: hg19 chr11:30,344,649-30,359,165 Size: 14,517 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr11:30,352,496-30,358,342 Size: 5,847 Coding Exon Count: 3
ID:AL14E_HUMAN DESCRIPTION: RecName: Full=ARL14 effector protein; AltName: Full=ARF7 effector protein; FUNCTION: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. SUBUNIT: Interacts with ARL14 and MYO1E. INTERACTION: Q8N4G2:ARL14; NbExp=3; IntAct=EBI-2807994, EBI-3921493; Q12965:MYO1E; NbExp=2; IntAct=EBI-2807994, EBI-4279548; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in the immune system.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF14949 - ARF7 effector protein C-terminus
ModBase Predicted Comparative 3D Structure on Q8N8R7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.