Description: Homo sapiens calreticulin 3 (CALR3), mRNA. RefSeq Summary (NM_145046): The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]. Transcript (Including UTRs) Position: hg19 chr19:16,589,868-16,607,003 Size: 17,136 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr19:16,589,942-16,606,940 Size: 16,999 Coding Exon Count: 9
ID:CALR3_HUMAN DESCRIPTION: RecName: Full=Calreticulin-3; AltName: Full=Calreticulin-2; AltName: Full=Calsperin; Flags: Precursor; FUNCTION: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. SUBUNIT: Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. TISSUE SPECIFICITY: Testis specific. DOMAIN: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity). DOMAIN: The interaction with glycans occurs through a binding site in the globular lectin domain (By similarity). DOMAIN: The zinc binding sites are localized to the N-domain (By similarity). DISEASE: Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19) [MIM:613875]. CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. SIMILARITY: Belongs to the calreticulin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96L12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0030246 carbohydrate binding GO:0044183 protein binding involved in protein folding GO:0046872 metal ion binding GO:0051082 unfolded protein binding GO:0005509 calcium ion binding
US Server
