Description: Homo sapiens tachykinin receptor 1 (TACR1), transcript variant long, mRNA. RefSeq Summary (NM_001058): This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]. Transcript (Including UTRs) Position: hg19 chr2:75,273,590-75,426,645 Size: 153,056 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr2:75,276,559-75,426,060 Size: 149,502 Coding Exon Count: 5
ID:NK1R_HUMAN DESCRIPTION: RecName: Full=Substance-P receptor; Short=SPR; AltName: Full=NK-1 receptor; Short=NK-1R; AltName: Full=Tachykinin receptor 1; FUNCTION: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. SUBUNIT: Interacts with ARRB1 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=Tachykinin entry; URL="http://en.wikipedia.org/wiki/Tachykinin";
Hip Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903296]
The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
slow transit constipation Garcia-Barcelo, M. et al. 2007, Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation, J Pediatr Surg 2007 42(4) 666-71.
[PubMed 17448763]
Our data indicate that 5 SNPs in the NOS1, TACR1, TACR3, and KIT genes could be involved in STC, especially rs3771863 in intron 1 of TACR1, which showed the highest association.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25103
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.