ID:KIF3A_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF3A; AltName: Full=Microtubule plus end-directed kinesin motor 3A; FUNCTION: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity). SUBUNIT: Heterodimer of KIF3A and KIF3B. Interacts with PIFO. Interacts with CLN3. INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-1104844, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). Cell projection, cilium (By similarity). SIMILARITY: Belongs to the kinesin-like protein family. Kinesin II subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAC04475.1; Type=Erroneous gene model prediction; Sequence=BAD93017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Dermatitis, Atopic Lavinia Paternoster et al. Nature genetics 2012, Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis., Nature genetics.
[PubMed 22197932]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y496
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006996 organelle organization GO:0007018 microtubule-based movement GO:0010457 centriole-centriole cohesion GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0022008 neurogenesis GO:0030030 cell projection organization GO:0034454 microtubule anchoring at centrosome GO:0035735 intraciliary transport involved in cilium assembly GO:0060271 cilium assembly GO:0072383 plus-end-directed vesicle transport along microtubule
JD330923 - Sequence 311947 from Patent EP1572962. JD242681 - Sequence 223705 from Patent EP1572962. JD511967 - Sequence 492991 from Patent EP1572962. JD220922 - Sequence 201946 from Patent EP1572962. BC045542 - Homo sapiens kinesin family member 3A, mRNA (cDNA clone MGC:57178 IMAGE:5298675), complete cds. AB209780 - Homo sapiens mRNA for Kinesin-like protein KIF3A variant protein. AK295089 - Homo sapiens cDNA FLJ60533 complete cds, highly similar to Kinesin-like protein KIF3A. AF041853 - Homo sapiens kinesin family member protein KIF3A mRNA, complete cds. AM177178 - Homo sapiens mRNA for kinesin-like protein KIF3Abeta (KIF3A gene). AK313359 - Homo sapiens cDNA, FLJ93885. KJ904667 - Synthetic construct Homo sapiens clone ccsbBroadEn_14061 KIF3A gene, encodes complete protein. AB463090 - Synthetic construct DNA, clone: pF1KB5220, Homo sapiens KIF3A gene for kinesin family member 3A, without stop codon, in Flexi system. BC020890 - Homo sapiens kinesin family member 3A, mRNA (cDNA clone IMAGE:4693968), partial cds. BC039592 - Homo sapiens, clone IMAGE:5403936, mRNA, partial cds. BC032599 - Homo sapiens kinesin family member 3A, mRNA (cDNA clone IMAGE:5533541), partial cds. CU692264 - Synthetic construct Homo sapiens gateway clone IMAGE:100020952 5' read KIF3A mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y496 (Reactome details) participates in the following event(s):