Description: Homo sapiens vacuolar protein sorting 11 homolog (S. cerevisiae) (VPS11), mRNA. RefSeq Summary (NM_021729): Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. Transcript (Including UTRs) Position: hg19 chr11:118,938,493-118,952,688 Size: 14,196 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr11:118,938,535-118,952,333 Size: 13,799 Coding Exon Count: 17
ID:VPS11_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 11 homolog; Short=hVPS11; AltName: Full=RING finger protein 108; FUNCTION: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. SUBUNIT: Part of large heterooligomeric complex together with VPS16, VPS18 and VPS33A. Interacts with STX7. Interacts with ECM29. INTERACTION: P35226:BMI1; NbExp=2; IntAct=EBI-373380, EBI-2341576; SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. TISSUE SPECIFICITY: Ubiquitous. Expression was highest in heart and low in lung. SIMILARITY: Belongs to the VPS11 family. SIMILARITY: Contains 1 clathrin repeat. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=AAG23761.1; Type=Frameshift; Positions=439, 924; Sequence=BAB15320.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00637 - Region in Clathrin and VPS PF12451 - Vacuolar protein sorting protein 11 C terminal PF13639 - Ring finger domain PF13923 - Zinc finger, C3HC4 type (RING finger)
ModBase Predicted Comparative 3D Structure on Q9H270
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006904 vesicle docking involved in exocytosis GO:0006914 autophagy GO:0007032 endosome organization GO:0007040 lysosome organization GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0031647 regulation of protein stability GO:0034058 endosomal vesicle fusion GO:0035542 regulation of SNARE complex assembly GO:1902115 regulation of organelle assembly GO:1903364 positive regulation of cellular protein catabolic process GO:1903955 positive regulation of protein targeting to mitochondrion GO:2000643 positive regulation of early endosome to late endosome transport
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