Human Gene GAGE2C (uc004dno.4) Description and Page Index
Description: Homo sapiens G antigen 2C (GAGE2C), mRNA. RefSeq Summary (NM_001472): This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:49,197,563-49,214,430 Size: 16,868 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chrX:49,198,719-49,214,326 Size: 15,608 Coding Exon Count: 4
ID:GAG2B_HUMAN DESCRIPTION: RecName: Full=G antigen 2B/2C; Short=GAGE-2B; Short=GAGE-2C; AltName: Full=Cancer/testis antigen 4.2; Short=CT4.2; AltName: Full=G antigen 2C; FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in normal tissues, except testis. MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells. SIMILARITY: Belongs to the GAGE family. CAUTION: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13066
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary