Human Gene GK2 (uc003hlu.3)
Description: Homo sapiens glycerol kinase 2 (GK2), mRNA.
Transcript (Including UTRs)
Position: hg19 chr4:80,327,507-80,329,372 Size: 1,866 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr4:80,327,693-80,329,354 Size: 1,662 Coding Exon Count: 1
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: GLPK2_HUMAN
DESCRIPTION: RecName: Full=Glycerol kinase 2; Short=GK 2; Short=Glycerokinase 2; EC=2.7.1.30; AltName: Full=ATP:glycerol 3-phosphotransferase 2; AltName: Full=Glycerol kinase, testis specific 2;
FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism (By similarity).CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3- phosphate.PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.SUBCELLULAR LOCATION: Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm (By similarity). Note=In sperm the majority of the enzyme is bound to mitochondria (By similarity).SIMILARITY: Belongs to the FGGY kinase family.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GK2
CDC HuGE Published Literature: GK2
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR018485 - Carb_kinase_FGGY_C
IPR018483 - Carb_kinase_FGGY_CS
IPR018484 - Carb_kinase_FGGY_N
IPR005999 - Glycerol_kin
Pfam Domains: PF00370 - FGGY family of carbohydrate kinases, N-terminal domain
PF02782 - FGGY family of carbohydrate kinases, C-terminal domain
SCOP Domains: 53067 - Actin-like ATPase domain
ModBase Predicted Comparative 3D Structure on Q14410
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK292241 - Homo sapiens cDNA FLJ75853 complete cds, highly similar to Homo sapiens glycerol kinase 2 (GK2), mRNA.X78712 - H.sapiens mRNA for glycerol kinase testis specific 2.HM005700 - Homo sapiens clone HTL-T-77m testis tissue sperm-binding protein Li 77m mRNA, complete cds.BC058888 - Homo sapiens glycerol kinase 2, mRNA (cDNA clone MGC:64903 IMAGE:5172337), complete cds.BC029820 - Homo sapiens glycerol kinase 2, mRNA (cDNA clone MGC:35147 IMAGE:5169374), complete cds.BC027598 - Homo sapiens cDNA clone IMAGE:4827415, containing frame-shift errors.BC048274 - Homo sapiens glycerol kinase 2, mRNA (cDNA clone MGC:51785 IMAGE:5166566), complete cds.AK312768 - Homo sapiens cDNA, FLJ93182.DQ891321 - Synthetic construct clone IMAGE:100003951; FLH171069.01X; RZPDo839E09100D glycerol kinase 2 (GK2) gene, encodes complete protein.KJ896885 - Synthetic construct Homo sapiens clone ccsbBroadEn_06279 GK2 gene, encodes complete protein.KJ905204 - Synthetic construct Homo sapiens clone ccsbBroadEn_14656 GK2 gene, encodes complete protein.DQ894505 - Synthetic construct Homo sapiens clone IMAGE:100008965; FLH171065.01L; RZPDo839E0999D glycerol kinase 2 (GK2) gene, encodes complete protein.CU688758 - Synthetic construct Homo sapiens gateway clone IMAGE:100019849 5' read GK2 mRNA.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A8K876, GKP2, GKTA, GLPK2_HUMAN, NM_033214, NP_149991, Q14410, Q6PD73, Q86XV8UCSC ID: uc003hlu.3RefSeq Accession: NM_033214
Protein: Q14410
(aka GLPK2_HUMAN)
CCDS: CCDS3585.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_033214.2
exon count:
1 CDS single in 3' UTR:
no
RNA size:
1899
ORF size:
1662 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3524.00 frame shift in genome:
no
% Coverage:
98.26
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.