Human Gene CCDC173 (uc002ufe.2) Description and Page Index
  Description: Homo sapiens coiled-coil domain containing 173 (CCDC173), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:170,501,935-170,550,931 Size: 48,997 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr2:170,502,351-170,550,837 Size: 48,487 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:170,501,935-170,550,931)mRNA (may differ from genome)Protein (552 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 173;
CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
SEQUENCE CAUTION: Sequence=AAI17446.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.38 RPKM in Testis
Total median expression: 78.20 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.4294-0.313 Picture PostScript Text
3' UTR -70.10416-0.169 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF13868 - Trichohyalin-plectin-homology domain

ModBase Predicted Comparative 3D Structure on Q0VFZ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Descriptions from all associated GenBank mRNAs
  AK301851 - Homo sapiens cDNA FLJ59063 complete cds.
BC117445 - Homo sapiens chromosome 2 open reading frame 77, mRNA (cDNA clone MGC:151054 IMAGE:40125996), complete cds.
HQ258289 - Synthetic construct Homo sapiens clone IMAGE:100072598 Unknown protein gene, encodes complete protein.
KJ903756 - Synthetic construct Homo sapiens clone ccsbBroadEn_13150 C2orf77 gene, encodes complete protein.
BC065905 - Homo sapiens chromosome 2 open reading frame 77, mRNA (cDNA clone IMAGE:6103613).
BC015980 - Homo sapiens chromosome 2 open reading frame 77, mRNA (cDNA clone IMAGE:3935159), partial cds.
JD313022 - Sequence 294046 from Patent EP1572962.
AK001460 - Homo sapiens cDNA FLJ10598 fis, clone NT2RP2004841.
JD454579 - Sequence 435603 from Patent EP1572962.
JD560840 - Sequence 541864 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C2orf77, CC173_HUMAN, NM_001085447, NP_001078916, Q0VFZ6, Q6PJF6
UCSC ID: uc002ufe.2
RefSeq Accession: NM_001085447
Protein: Q0VFZ6 (aka CC173_HUMAN)
CCDS: CCDS46445.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001085447.1
exon count: 9CDS single in 3' UTR: no RNA size: 2187
ORF size: 1659CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3307.00frame shift in genome: no % Coverage: 99.18
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.