Human Gene FAM187B (uc002nyk.1) Description and Page Index
  Description: Homo sapiens family with sequence similarity 187, member B (FAM187B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:35,715,704-35,719,628 Size: 3,925 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:35,715,728-35,719,583 Size: 3,856 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:35,715,704-35,719,628)mRNA (may differ from genome)Protein (369 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: F187B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM187B; AltName: Full=Transmembrane protein 162; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Belongs to the FAM187 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 69.20 RPKM in Testis
Total median expression: 70.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.3045-0.296 Picture PostScript Text
3' UTR -3.6024-0.150 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q17R55
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK098526 - Homo sapiens cDNA FLJ25660 fis, clone TST00449.
BC117457 - Homo sapiens family with sequence similarity 187, member B, mRNA (cDNA clone MGC:151066 IMAGE:40126008), complete cds.
BC039080 - Homo sapiens, hypothetical protein FLJ25660, clone IMAGE:5166433, mRNA.
BC117459 - Homo sapiens family with sequence similarity 187, member B, mRNA (cDNA clone MGC:151068 IMAGE:40126010), complete cds.
HQ258231 - Synthetic construct Homo sapiens clone IMAGE:100072540 family with sequence similarity 187, member B (FAM187B) gene, encodes complete protein.
KJ900260 - Synthetic construct Homo sapiens clone ccsbBroadEn_09654 FAM187B gene, encodes complete protein.
JD149062 - Sequence 130086 from Patent EP1572962.
JD493239 - Sequence 474263 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: F187B_HUMAN, NM_152481, NP_689694, Q17R55, Q8N7G6, TMEM162
UCSC ID: uc002nyk.1
RefSeq Accession: NM_152481
Protein: Q17R55 (aka F187B_HUMAN)
CCDS: CCDS12448.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152481.1
exon count: 2CDS single in 3' UTR: no RNA size: 1179
ORF size: 1110CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2398.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.