Human Gene ZPBP2 (uc002hte.3) Description and Page Index
  Description: Homo sapiens zona pellucida binding protein 2 (ZPBP2), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:38,024,455-38,034,149 Size: 9,695 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr17:38,024,608-38,033,062 Size: 8,455 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:38,024,455-38,034,149)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zona pellucida-binding protein 2; AltName: Full=ZPBP-like protein; Flags: Precursor;
FUNCTION: May be implicated in gamete interaction during fertilization.
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the zona pellucida-binding protein Sp38 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZPBP2
CDC HuGE Published Literature: ZPBP2
Positive Disease Associations: Arthritis, Rheumatoid , Colitis, Ulcerative , Crohn Disease , Diabetes Mellitus, Type 1
Related Studies:
  1. Arthritis, Rheumatoid
    Eli A Stahl et al. Nature genetics 2010, Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., Nature genetics. [PubMed 20453842]
  2. Colitis, Ulcerative
    Dermot P B McGovern et al. Nature genetics 2010, Genome-wide association identifies multiple ulcerative colitis susceptibility loci., Nature genetics. [PubMed 20228799]
  3. Colitis, Ulcerative
    Carl A Anderson et al. Nature genetics 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47., Nature genetics. [PubMed 21297633]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.04 RPKM in Testis
Total median expression: 71.17 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.10153-0.510 Picture PostScript Text
3' UTR -238.491087-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR010857 - Sp38-bd

Pfam Domains:
PF07354 - Zona-pellucida-binding protein (Sp38)

ModBase Predicted Comparative 3D Structure on Q6X784
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001675 acrosome assembly
GO:0007339 binding of sperm to zona pellucida

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0002199 zona pellucida receptor complex
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0031410 cytoplasmic vesicle
GO:0044297 cell body

-  Descriptions from all associated GenBank mRNAs
  AK292383 - Homo sapiens cDNA FLJ75797 complete cds, highly similar to Homo sapiens zona pellucida binding protein 2 (ZPBP2), transcript variant 2, mRNA.
BC043152 - Homo sapiens zona pellucida binding protein 2, mRNA (cDNA clone MGC:41930 IMAGE:5297840), complete cds.
AY251603 - Homo sapiens zona pellucida binding protein 2 (ZPBP2) mRNA, complete cds.
AY251604 - Homo sapiens zona pellucida binding protein 2 (ZPBP2) mRNA, complete cds; alternative transcript.
JD344476 - Sequence 325500 from Patent EP1572962.
KJ900822 - Synthetic construct Homo sapiens clone ccsbBroadEn_10216 ZPBP2 gene, encodes complete protein.
DQ573438 - Homo sapiens piRNA piR-41550, complete sequence.
JD170897 - Sequence 151921 from Patent EP1572962.
JD284792 - Sequence 265816 from Patent EP1572962.
JD516169 - Sequence 497193 from Patent EP1572962.
JD508986 - Sequence 490010 from Patent EP1572962.
JD299474 - Sequence 280498 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8L8, NM_199321, NP_955353, Q6X783, Q6X784, Q86XL5, ZPBP2_HUMAN, ZPBPL
UCSC ID: uc002hte.3
RefSeq Accession: NM_199321
Protein: Q6X784 (aka ZPBP2_HUMAN or ZPB2_HUMAN)
CCDS: CCDS11352.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_199321.2
exon count: 8CDS single in 3' UTR: no RNA size: 2271
ORF size: 1017CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2198.00frame shift in genome: no % Coverage: 99.38
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.