ID:ZPBP2_HUMAN DESCRIPTION: RecName: Full=Zona pellucida-binding protein 2; AltName: Full=ZPBP-like protein; Flags: Precursor; FUNCTION: May be implicated in gamete interaction during fertilization. SUBCELLULAR LOCATION: Secreted (Potential). SIMILARITY: Belongs to the zona pellucida-binding protein Sp38 family.
Genetic Association Studies of Complex Diseases and Disorders
Arthritis, Rheumatoid Eli A Stahl et al. Nature genetics 2010, Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., Nature genetics.
Colitis, Ulcerative Dermot P B McGovern et al. Nature genetics 2010, Genome-wide association identifies multiple ulcerative colitis susceptibility loci., Nature genetics.
Colitis, Ulcerative Carl A Anderson et al. Nature genetics 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47., Nature genetics.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07354 - Zona-pellucida-binding protein (Sp38)
ModBase Predicted Comparative 3D Structure on Q6X784
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.