Human Gene KCTD19 (uc002esu.2) Description and Page Index
  Description: Homo sapiens potassium channel tetramerisation domain containing 19 (KCTD19), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:67,323,393-67,360,661 Size: 37,269 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr16:67,323,472-67,360,610 Size: 37,139 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:67,323,393-67,360,661)mRNA (may differ from genome)Protein (926 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIneXtProtPubMed
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: KCD19_HUMAN
DESCRIPTION: RecName: Full=BTB/POZ domain-containing protein KCTD19;
SIMILARITY: Contains 2 BTB (POZ) domains.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KCTD19
CDC HuGE Published Literature: KCTD19
Positive Disease Associations: Glucose , Lipoproteins, HDL
Related Studies:
  1. Glucose
    , , . [PubMed 0]
  2. Lipoproteins, HDL
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: KCTD19
Diseases sorted by gene-association score: cerebral visual impairment (9)

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.57 RPKM in Testis
Total median expression: 53.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.0051-0.333 Picture PostScript Text
3' UTR -13.2979-0.168 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011333 - BTB/POZ_fold
IPR003131 - T1-type_BTB

Pfam Domains:
PF02214 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q17RG1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051260 protein homooligomerization


-  Descriptions from all associated GenBank mRNAs
  BC070103 - Homo sapiens potassium channel tetramerisation domain containing 19, mRNA (cDNA clone IMAGE:5268205).
BC094790 - Homo sapiens cDNA clone IMAGE:5267863.
AK302567 - Homo sapiens cDNA FLJ52078 complete cds, highly similar to Mus musculus potassium channel tetramerisation domain containing 19 (Kctd19), mRNA.
AK302748 - Homo sapiens cDNA FLJ52079 complete cds, highly similar to Mus musculus potassium channel tetramerisation domain containing 19 (Kctd19), mRNA.
BC117335 - Homo sapiens potassium channel tetramerisation domain containing 19, mRNA (cDNA clone MGC:150944 IMAGE:40125886), complete cds.
HM005414 - Homo sapiens clone HTL-T-101 testicular tissue protein Li 101 mRNA, complete cds.
JD335873 - Sequence 316897 from Patent EP1572962.
JD146360 - Sequence 127384 from Patent EP1572962.
HQ258662 - Synthetic construct Homo sapiens clone IMAGE:100072692 potassium channel tetramerisation domain containing 19 (KCTD19) gene, encodes complete protein.
KJ895588 - Synthetic construct Homo sapiens clone ccsbBroadEn_04982 KCTD19 gene, encodes complete protein.
DQ594562 - Homo sapiens piRNA piR-60674, complete sequence.
JD164899 - Sequence 145923 from Patent EP1572962.
AK097481 - Homo sapiens cDNA FLJ40162 fis, clone TESTI2015752.
DQ597647 - Homo sapiens piRNA piR-35713, complete sequence.
DQ580533 - Homo sapiens piRNA piR-48645, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DZ49, KCD19_HUMAN, NM_001100915, NP_001094385, Q17RG1, Q8N804
UCSC ID: uc002esu.2
RefSeq Accession: NM_001100915
Protein: Q17RG1 (aka KCD19_HUMAN)
CCDS: CCDS42179.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001100915.1
exon count: 16CDS single in 3' UTR: no RNA size: 2911
ORF size: 2781CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5762.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.