Human Gene TBC1D21 (uc002avz.3) Description and Page Index
  Description: Homo sapiens TBC1 domain family, member 21 (TBC1D21), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:74,165,968-74,181,556 Size: 15,589 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr15:74,166,051-74,181,442 Size: 15,392 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:74,165,968-74,181,556)mRNA (may differ from genome)Protein (336 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=TBC1 domain family member 21;
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).
SIMILARITY: Contains 1 Rab-GAP TBC domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.87 RPKM in Testis
Total median expression: 51.95 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.5083-0.319 Picture PostScript Text
3' UTR -31.80114-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000195 - Rab-GTPase-TBC_dom

Pfam Domains:
PF00566 - Rab-GTPase-TBC domain

SCOP Domains:
47923 - Ypt/Rab-GAP domain of gyp1p

ModBase Predicted Comparative 3D Structure on Q8IYX1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005096 GTPase activator activity
GO:0017137 Rab GTPase binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0031338 regulation of vesicle fusion
GO:0090630 activation of GTPase activity
GO:1902017 regulation of cilium assembly

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0012505 endomembrane system
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  BC033516 - Homo sapiens TBC1 domain family, member 21, mRNA (cDNA clone MGC:34741 IMAGE:5170475), complete cds.
KJ895717 - Synthetic construct Homo sapiens clone ccsbBroadEn_05111 TBC1D21 gene, encodes complete protein.
AB449907 - Homo sapiens TBC1D21 mRNA for TBC1 domain family, member 21, complete cds.
JD284180 - Sequence 265204 from Patent EP1572962.
JD454041 - Sequence 435065 from Patent EP1572962.
JD174475 - Sequence 155499 from Patent EP1572962.
JD277836 - Sequence 258860 from Patent EP1572962.
JD474152 - Sequence 455176 from Patent EP1572962.
JD180912 - Sequence 161936 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_153356, NP_699187, Q8IYX1, TBC21_HUMAN
UCSC ID: uc002avz.3
RefSeq Accession: NM_153356
Protein: Q8IYX1 (aka TBC21_HUMAN)
CCDS: CCDS10252.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_153356.1
exon count: 11CDS single in 3' UTR: no RNA size: 1256
ORF size: 1011CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 2222.00frame shift in genome: no % Coverage: 96.18
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.