Description: Homo sapiens limbic system-associated membrane protein (LSAMP), mRNA. RefSeq Summary (NM_002338): This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr3:115,521,210-116,164,385 Size: 643,176 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr3:115,529,164-116,163,878 Size: 634,715 Coding Exon Count: 7
ID:LSAMP_HUMAN DESCRIPTION: RecName: Full=Limbic system-associated membrane protein; Short=LSAMP; AltName: Full=IgLON family member 3; Flags: Precursor; FUNCTION: Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity). INTERACTION: Q7Z3B1:NEGR1; NbExp=2; IntAct=EBI-4314821, EBI-4314838; Q9P121:NTM; NbExp=2; IntAct=EBI-4314821, EBI-4315078; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum. SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Mental Competency Kathryn L Lunetta et al. BMC medical genetics 2007, Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study., BMC medical genetics.
[PubMed 17903295]
Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13449
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
