Description: Homo sapiens large subunit GTPase 1 homolog (S. cerevisiae) (LSG1), mRNA. RefSeq Summary (NM_018385): This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr3:194,361,517-194,393,206 Size: 31,690 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr3:194,362,797-194,392,891 Size: 30,095 Coding Exon Count: 14
ID:LSG1_HUMAN DESCRIPTION: RecName: Full=Large subunit GTPase 1 homolog; Short=hLsg1; EC=3.6.1.-; FUNCTION: GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum. Nucleus, Cajal body. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum. DOMAIN: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern. SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family. LSG1 subfamily. SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. SEQUENCE CAUTION: Sequence=AAH15042.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH40119.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H089
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
