Description: Homo sapiens fms-related tyrosine kinase 3 ligand (FLT3LG), transcript variant 1, mRNA. RefSeq Summary (NM_001204502): Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr19:49,977,466-49,989,488 Size: 12,023 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr19:49,977,897-49,983,856 Size: 5,960 Coding Exon Count: 7
ID:FLT3L_HUMAN DESCRIPTION: RecName: Full=Fms-related tyrosine kinase 3 ligand; Short=Flt3 ligand; Short=Flt3L; AltName: Full=SL cytokine; Flags: Precursor; FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. SUBUNIT: Homodimer (isoform 2). SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49771
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0007165 signal transduction GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030098 lymphocyte differentiation GO:0030885 regulation of myeloid dendritic cell activation GO:0032819 positive regulation of natural killer cell proliferation GO:0032825 positive regulation of natural killer cell differentiation GO:0035162 embryonic hemopoiesis GO:0045663 positive regulation of myoblast differentiation GO:0045787 positive regulation of cell cycle GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048873 homeostasis of number of cells within a tissue GO:0071864 positive regulation of cell proliferation in bone marrow GO:0071866 negative regulation of apoptotic process in bone marrow GO:0090290 positive regulation of osteoclast proliferation GO:1901741 positive regulation of myoblast fusion
US Server
