Human Gene SLC25A43 (uc004erd.3)
  Description: Homo sapiens solute carrier family 25, member 43 (SLC25A43), nuclear gene encoding mitochondrial protein, mRNA.
RefSeq Summary (NM_145305): This gene encodes a member of the mitochondrial carrier family of proteins.[provided by RefSeq, Dec 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chrX:118,533,258-118,588,437 Size: 55,180 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chrX:118,533,367-118,587,028 Size: 53,662 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:118,533,258-118,588,437)mRNA (may differ from genome)Protein (341 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S2543_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 25 member 43;
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.
SEQUENCE CAUTION: Sequence=AAC62432.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.22 RPKM in Esophagus - Mucosa
Total median expression: 248.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.60109-0.648 Picture PostScript Text
3' UTR -374.011409-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8WUT9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
      
      
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC019584 - Homo sapiens solute carrier family 25, member 43, mRNA (cDNA clone MGC:24996 IMAGE:4939064), complete cds.
AK094254 - Homo sapiens cDNA FLJ36935 fis, clone BRACE2005363, weakly similar to BRITTLE-1 PROTEIN PRECURSOR.
BC071871 - Homo sapiens solute carrier family 25, member 43, mRNA (cDNA clone MGC:88544 IMAGE:6497491), complete cds.
JD458853 - Sequence 439877 from Patent EP1572962.
AK303932 - Homo sapiens cDNA FLJ58871 complete cds.
AK091304 - Homo sapiens cDNA FLJ33985 fis, clone DFNES2005766, weakly similar to GRAVE'S DISEASE CARRIER PROTEIN.
AX746905 - Sequence 430 from Patent EP1308459.
AK292035 - Homo sapiens cDNA FLJ77355 complete cds.
JD487903 - Sequence 468927 from Patent EP1572962.
CU676444 - Synthetic construct Homo sapiens gateway clone IMAGE:100019014 5' read SLC25A43 mRNA.
HQ447835 - Synthetic construct Homo sapiens clone IMAGE:100071179; CCSB008123_01 solute carrier family 25, member 43 (SLC25A43) gene, encodes complete protein.
KJ900434 - Synthetic construct Homo sapiens clone ccsbBroadEn_09828 SLC25A43 gene, encodes complete protein.
AL590525 - Novel human mRNA from X chromosome.
JD438096 - Sequence 419120 from Patent EP1572962.
JD305585 - Sequence 286609 from Patent EP1572962.
JD265755 - Sequence 246779 from Patent EP1572962.
JD062495 - Sequence 43519 from Patent EP1572962.
JD203077 - Sequence 184101 from Patent EP1572962.
JD037438 - Sequence 18462 from Patent EP1572962.
JD059512 - Sequence 40536 from Patent EP1572962.
JD534708 - Sequence 515732 from Patent EP1572962.
JD042436 - Sequence 23460 from Patent EP1572962.
JD386377 - Sequence 367401 from Patent EP1572962.
JD281543 - Sequence 262567 from Patent EP1572962.
JD533677 - Sequence 514701 from Patent EP1572962.
JD198305 - Sequence 179329 from Patent EP1572962.
JD152944 - Sequence 133968 from Patent EP1572962.
JD049995 - Sequence 31019 from Patent EP1572962.
JD531240 - Sequence 512264 from Patent EP1572962.
JD084927 - Sequence 65951 from Patent EP1572962.
JD248827 - Sequence 229851 from Patent EP1572962.
JD349156 - Sequence 330180 from Patent EP1572962.
JD156251 - Sequence 137275 from Patent EP1572962.
JD535561 - Sequence 516585 from Patent EP1572962.
JD071487 - Sequence 52511 from Patent EP1572962.
JD241290 - Sequence 222314 from Patent EP1572962.
JD425853 - Sequence 406877 from Patent EP1572962.
JD348640 - Sequence 329664 from Patent EP1572962.
JD308303 - Sequence 289327 from Patent EP1572962.
JD425947 - Sequence 406971 from Patent EP1572962.
JD478461 - Sequence 459485 from Patent EP1572962.
JD120465 - Sequence 101489 from Patent EP1572962.
JD310542 - Sequence 291566 from Patent EP1572962.
JD140762 - Sequence 121786 from Patent EP1572962.
JD199890 - Sequence 180914 from Patent EP1572962.
JD422201 - Sequence 403225 from Patent EP1572962.
JD551532 - Sequence 532556 from Patent EP1572962.
JD276445 - Sequence 257469 from Patent EP1572962.
JD284520 - Sequence 265544 from Patent EP1572962.
JD509285 - Sequence 490309 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_145305, NP_660348, O75854, Q8N9L5, Q8WUT9, S2543_HUMAN
UCSC ID: uc004erd.3
RefSeq Accession: NM_145305
Protein: Q8WUT9 (aka S2543_HUMAN)
CCDS: CCDS14577.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_145305.2
exon count: 5CDS single in 3' UTR: no RNA size: 2557
ORF size: 1026CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1930.00frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.