Description: Homo sapiens F-box protein 42 (FBXO42), mRNA. RefSeq Summary (NM_018994): Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]. Transcript (Including UTRs) Position: hg19 chr1:16,576,559-16,678,948 Size: 102,390 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr1:16,577,165-16,641,913 Size: 64,749 Coding Exon Count: 9
ID:FBX42_HUMAN DESCRIPTION: RecName: Full=F-box only protein 42; AltName: Full=Just one F-box and Kelch domain-containing protein; FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. SUBUNIT: Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 4 Kelch repeats. SEQUENCE CAUTION: Sequence=CAI22561.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P3S6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
