Description: Homo sapiens NLR family member X1 (NLRX1), transcript variant 1, mRNA. RefSeq Summary (NM_024618): The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]. Transcript (Including UTRs) Position: hg19 chr11:119,039,440-119,054,725 Size: 15,286 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr11:119,042,113-119,054,148 Size: 12,036 Coding Exon Count: 9
ID:NLRX1_HUMAN DESCRIPTION: RecName: Full=NLR family member X1; AltName: Full=Caterpiller protein 11.3; Short=CLR11.3; AltName: Full=Nucleotide-binding oligomerization domain protein 26; AltName: Full=Nucleotide-binding oligomerization domain protein 5; AltName: Full=Nucleotide-binding oligomerization domain protein 9; Flags: Precursor; FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). SUBUNIT: Interacts with MAVS. INTERACTION: Q6PDS3:Sarm1 (xeno); NbExp=2; IntAct=EBI-3893071, EBI-6117196; SUBCELLULAR LOCATION: Mitochondrion outer membrane. TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). SIMILARITY: Belongs to the NLRP family. SIMILARITY: Contains 7 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 NACHT domain. SEQUENCE CAUTION: Sequence=BAB15075.1; Type=Erroneous initiation; Sequence=BAG51714.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG51714.1; Type=Erroneous termination; Positions=951; Note=Translated as Trp;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86UT6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0016032 viral process GO:0032480 negative regulation of type I interferon production GO:0032688 negative regulation of interferon-beta production GO:0032715 negative regulation of interleukin-6 production GO:0039536 negative regulation of RIG-I signaling pathway GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0045087 innate immune response GO:0045824 negative regulation of innate immune response GO:0050728 negative regulation of inflammatory response
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