Human Gene TMEM255B (uc001vuh.3)
  Description: Homo sapiens transmembrane protein 255B (TMEM255B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr13:114,462,216-114,514,899 Size: 52,684 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr13:114,462,243-114,514,876 Size: 52,634 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:114,462,216-114,514,899)mRNA (may differ from genome)Protein (326 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FA70B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM70B;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the FAM70 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.26 RPKM in Thyroid
Total median expression: 177.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.3027-0.456 Picture PostScript Text
3' UTR 0.00230.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14967 - FAM70 protein

ModBase Predicted Comparative 3D Structure on Q8WV15
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC018995 - Homo sapiens family with sequence similarity 70, member B, mRNA (cDNA clone MGC:20579 IMAGE:4300679), complete cds.
AK295653 - Homo sapiens cDNA FLJ57938 complete cds.
KJ896118 - Synthetic construct Homo sapiens clone ccsbBroadEn_05512 FAM70B gene, encodes complete protein.
JD408263 - Sequence 389287 from Patent EP1572962.
EU831540 - Synthetic construct Homo sapiens clone HAIB:100066569; DKFZo004E0518 family with sequence similarity 70, member B protein (FAM70B) gene, encodes complete protein.
EU831453 - Synthetic construct Homo sapiens clone HAIB:100066482; DKFZo008E0517 family with sequence similarity 70, member B protein (FAM70B) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: FA70B_HUMAN, FAM70B, NM_182614, NP_872420, Q8WV15
UCSC ID: uc001vuh.3
RefSeq Accession: NM_182614
Protein: Q8WV15 (aka FA70B_HUMAN)
CCDS: CCDS45071.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182614.2
exon count: 9CDS single in 3' UTR: no RNA size: 1047
ORF size: 981CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2081.00frame shift in genome: no % Coverage: 98.47
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.