Description: Homo sapiens C-terminal binding protein 2 (CTBP2), transcript variant 2, mRNA. RefSeq Summary (NM_022802): This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. Transcript (Including UTRs) Position: hg19 chr10:126,676,418-126,716,453 Size: 40,036 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr10:126,678,087-126,716,328 Size: 38,242 Coding Exon Count: 9
prostate cancer Thomas ,et al. 2008, Multiple loci identified in a genome-wide association study of prostate cancer, Nature genetics 2008 40- 3 : 310-5.
[PubMed 18264096]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00389 - D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain PF02826 - D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
ModBase Predicted Comparative 3D Structure on P56545-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
