Human Gene ARSK (uc003kld.3)
  Description: Homo sapiens arylsulfatase family, member K (ARSK), mRNA.
RefSeq Summary (NM_198150): Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg19 chr5:94,890,825-94,940,806 Size: 49,982 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr5:94,890,983-94,939,230 Size: 48,248 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:94,890,825-94,940,806)mRNA (may differ from genome)Protein (536 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ARSK_HUMAN
DESCRIPTION: RecName: Full=Arylsulfatase K; Short=ASK; EC=3.1.6.-; AltName: Full=Telethon sulfatase; Flags: Precursor;
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBCELLULAR LOCATION: Secreted (Potential).
PTM: The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity).
SIMILARITY: Belongs to the sulfatase family.
SEQUENCE CAUTION: Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.94 RPKM in Cells - Cultured fibroblasts
Total median expression: 83.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.40158-0.338 Picture PostScript Text
3' UTR -388.171576-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017849 - Alkaline_Pase-like_a/b/a
IPR017850 - Alkaline_phosphatase_core
IPR000917 - Sulfatase

Pfam Domains:
PF00884 - Sulfatase

SCOP Domains:
53649 - Alkaline phosphatase-like

ModBase Predicted Comparative 3D Structure on Q6UWY0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0008152 metabolic process

Cellular Component:
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen


-  Descriptions from all associated GenBank mRNAs
  AK303855 - Homo sapiens cDNA FLJ50046 complete cds, highly similar to Arylsulfatase K precursor (EC 3.1.6.-).
AK316253 - Homo sapiens cDNA, FLJ79152 complete cds, highly similar to Arylsulfatase K precursor (EC 3.1.6.-).
AY358596 - Homo sapiens clone DNA64885 Bone Rel Sulphatase (UNQ630) mRNA, complete cds.
BC050392 - Homo sapiens arylsulfatase family, member K, mRNA (cDNA clone IMAGE:5759220), partial cds.
BC130329 - Homo sapiens arylsulfatase family, member K, mRNA (cDNA clone MGC:163201 IMAGE:40146360), complete cds.
BC144160 - Homo sapiens cDNA clone IMAGE:9052680, with apparent retained intron.
BC144161 - Homo sapiens cDNA clone IMAGE:9052681.
BC036047 - Homo sapiens arylsulfatase family, member K, mRNA (cDNA clone IMAGE:5273316), partial cds.
HQ258292 - Synthetic construct Homo sapiens clone IMAGE:100072601 arylsulfatase family, member K (ARSK) gene, encodes complete protein.
KJ895681 - Synthetic construct Homo sapiens clone ccsbBroadEn_05075 ARSK gene, encodes complete protein.
AY875939 - Homo sapiens arylsulfatase K (ARSK) mRNA, complete cds.
BC015723 - Homo sapiens cDNA clone IMAGE:3920449, partial cds.
BC080567 - Homo sapiens cDNA clone IMAGE:6536768.
JD519692 - Sequence 500716 from Patent EP1572962.
JD538729 - Sequence 519753 from Patent EP1572962.
JD242073 - Sequence 223097 from Patent EP1572962.
JD453135 - Sequence 434159 from Patent EP1572962.
JD306629 - Sequence 287653 from Patent EP1572962.
AL832711 - Homo sapiens mRNA; cDNA DKFZp313G1735 (from clone DKFZp313G1735).
JD114785 - Sequence 95809 from Patent EP1572962.
JD096180 - Sequence 77204 from Patent EP1572962.
JD181928 - Sequence 162952 from Patent EP1572962.
JD212416 - Sequence 193440 from Patent EP1572962.
JD197808 - Sequence 178832 from Patent EP1572962.
JD412789 - Sequence 393813 from Patent EP1572962.
JD512757 - Sequence 493781 from Patent EP1572962.
JD238480 - Sequence 219504 from Patent EP1572962.
JD372852 - Sequence 353876 from Patent EP1572962.
JD432484 - Sequence 413508 from Patent EP1572962.
JD481555 - Sequence 462579 from Patent EP1572962.
JD450825 - Sequence 431849 from Patent EP1572962.
JD131055 - Sequence 112079 from Patent EP1572962.
JD414151 - Sequence 395175 from Patent EP1572962.
JD178679 - Sequence 159703 from Patent EP1572962.
JD448384 - Sequence 429408 from Patent EP1572962.
JD315274 - Sequence 296298 from Patent EP1572962.
JD430313 - Sequence 411337 from Patent EP1572962.
JD557453 - Sequence 538477 from Patent EP1572962.
JD529409 - Sequence 510433 from Patent EP1572962.
JD169670 - Sequence 150694 from Patent EP1572962.
JD169671 - Sequence 150695 from Patent EP1572962.
JD306328 - Sequence 287352 from Patent EP1572962.
JD055199 - Sequence 36223 from Patent EP1572962.
JD125626 - Sequence 106650 from Patent EP1572962.
JD125627 - Sequence 106651 from Patent EP1572962.
JD395430 - Sequence 376454 from Patent EP1572962.
JD066689 - Sequence 47713 from Patent EP1572962.
JD183984 - Sequence 165008 from Patent EP1572962.
JD092347 - Sequence 73371 from Patent EP1572962.
DL491446 - Novel nucleic acids.
JD558985 - Sequence 540009 from Patent EP1572962.
JD537912 - Sequence 518936 from Patent EP1572962.
JD461366 - Sequence 442390 from Patent EP1572962.
JD405307 - Sequence 386331 from Patent EP1572962.
JD048795 - Sequence 29819 from Patent EP1572962.
JD292090 - Sequence 273114 from Patent EP1572962.
JD093371 - Sequence 74395 from Patent EP1572962.
JD109518 - Sequence 90542 from Patent EP1572962.
JD389424 - Sequence 370448 from Patent EP1572962.
JD221335 - Sequence 202359 from Patent EP1572962.
AK126218 - Homo sapiens cDNA FLJ44230 fis, clone THYMU3006640.
JD507698 - Sequence 488722 from Patent EP1572962.
JD295265 - Sequence 276289 from Patent EP1572962.
JD224860 - Sequence 205884 from Patent EP1572962.
JD491011 - Sequence 472035 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6UWY0 (Reactome details) participates in the following event(s):

R-HSA-1614362 SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases
R-HSA-428157 Sphingolipid metabolism
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-556833 Metabolism of lipids
R-HSA-597592 Post-translational protein modification
R-HSA-1430728 Metabolism
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A2BDE3, ARSK_HUMAN, B4E1I4, NM_198150, NP_937793, Q3ZCW3, Q6UWY0, Q8N3Q8, TSULF, UNQ630/PRO1246
UCSC ID: uc003kld.3
RefSeq Accession: NM_198150
Protein: Q6UWY0 (aka ARSK_HUMAN)
CCDS: CCDS4073.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198150.2
exon count: 8CDS single in 3' UTR: no RNA size: 3345
ORF size: 1611CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3422.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.