Human Gene POM121L12 (uc003tpz.3)
  Description: Homo sapiens POM121 transmembrane nucleoporin-like 12 (POM121L12), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:53,103,349-53,104,618 Size: 1,270 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr7:53,103,365-53,104,255 Size: 891 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:53,103,349-53,104,618)mRNA (may differ from genome)Protein (296 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: P1L12_HUMAN
DESCRIPTION: RecName: Full=POM121-like protein 12;
SIMILARITY: Belongs to the POM121 family.
SEQUENCE CAUTION: Sequence=BAC05166.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD38744.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.82 RPKM in Testis
Total median expression: 13.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -0.9016-0.056 Picture PostScript Text
3' UTR -77.74363-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026054 - Nucleoporin
IPR026090 - POM121

Pfam Domains:
PF15229 - POM121 family

ModBase Predicted Comparative 3D Structure on Q8N7R1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008139 nuclear localization sequence binding
GO:0017056 structural constituent of nuclear pore

Biological Process:
GO:0006405 RNA export from nucleus
GO:0006606 protein import into nucleus

Cellular Component:
GO:0005622 intracellular
GO:0044613 nuclear pore central transport channel
GO:0044615 nuclear pore nuclear basket


-  Descriptions from all associated GenBank mRNAs
  AK097768 - Homo sapiens cDNA FLJ40449 fis, clone TESTI2040897, weakly similar to NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121.
AL833888 - Homo sapiens mRNA; cDNA DKFZp564N2472 (from clone DKFZp564N2472).
JD287564 - Sequence 268588 from Patent EP1572962.
JD247838 - Sequence 228862 from Patent EP1572962.
JD095518 - Sequence 76542 from Patent EP1572962.
JD163748 - Sequence 144772 from Patent EP1572962.
JD164343 - Sequence 145367 from Patent EP1572962.
JD408009 - Sequence 389033 from Patent EP1572962.
JD251668 - Sequence 232692 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_182595, NP_872401, P1L12_HUMAN, Q8N7R1, Q8NDI9
UCSC ID: uc003tpz.3
RefSeq Accession: NM_182595
Protein: Q8N7R1 (aka P1L12_HUMAN)
CCDS: CCDS43584.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182595.3
exon count: 1CDS single in 3' UTR: no RNA size: 1284
ORF size: 891CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1981.00frame shift in genome: no % Coverage: 98.91
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.