Human Gene MYT1 (uc002yii.3)
  Description: Homo sapiens myelin transcription factor 1 (MYT1), mRNA.
RefSeq Summary (NM_004535): The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr20:62,795,827-62,873,606 Size: 77,780 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg19 chr20:62,830,215-62,871,801 Size: 41,587 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:62,795,827-62,873,606)mRNA (may differ from genome)Protein (1121 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYT1_HUMAN
DESCRIPTION: RecName: Full=Myelin transcription factor 1; Short=MyT1; AltName: Full=Myelin transcription factor I; Short=MyTI; AltName: Full=PLPB1; AltName: Full=Proteolipid protein-binding protein;
FUNCTION: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
SUBUNIT: Interacts with STEAP3.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
DOMAIN: Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
SIMILARITY: Contains 7 C2HC-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAA74858.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MYT1
CDC HuGE Published Literature: MYT1
Positive Disease Associations: Basophils
Related Studies:
  1. Basophils
    , , . [PubMed 0]
  2. Basophils
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: MYT1
Diseases sorted by gene-association score: periventricular leukomalacia (31), hemifacial microsomia (7), leukomalacia (7), encephalomalacia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.74 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 96.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.13364-0.311 Picture PostScript Text
3' UTR -605.751805-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013681 - Myelin_TF
IPR002515 - Znf_C2HC

Pfam Domains:
PF01530 - Zinc finger, C2HC type
PF08474 - Myelin transcription factor 1

SCOP Domains:
103637 - CCHHC domain

ModBase Predicted Comparative 3D Structure on Q01538
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0030154 cell differentiation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC062313 - Homo sapiens myelin transcription factor 1, mRNA (cDNA clone MGC:71389 IMAGE:4301464), complete cds.
BC018917 - Homo sapiens myelin transcription factor 1, mRNA (cDNA clone IMAGE:4124248), partial cds.
AB020642 - Homo sapiens KIAA0835 mRNA for KIAA0835 protein.
JD179036 - Sequence 160060 from Patent EP1572962.
JD371801 - Sequence 352825 from Patent EP1572962.
JD156330 - Sequence 137354 from Patent EP1572962.
JD172839 - Sequence 153863 from Patent EP1572962.
JD131295 - Sequence 112319 from Patent EP1572962.
JD063754 - Sequence 44778 from Patent EP1572962.
CU687528 - Synthetic construct Homo sapiens gateway clone IMAGE:100023027 5' read MYT1 mRNA.
KJ901592 - Synthetic construct Homo sapiens clone ccsbBroadEn_10986 MYT1 gene, encodes complete protein.
AB385388 - Synthetic construct DNA, clone: pF1KA0835, Homo sapiens MYT1 gene for myelin transcription factor 1, complete cds, without stop codon, in Flexi system.
AB028973 - Homo sapiens mRNA for KIAA1050 protein, partial cds.
BC053638 - Homo sapiens myelin transcription factor 1, mRNA (cDNA clone IMAGE:4933873), partial cds.
M96980 - Homo sapiens myelin transcription factor 1 (MTF1) mRNA, 3' end.
JD099323 - Sequence 80347 from Patent EP1572962.
JD116472 - Sequence 97496 from Patent EP1572962.
JD341635 - Sequence 322659 from Patent EP1572962.
JD353412 - Sequence 334436 from Patent EP1572962.
JD437067 - Sequence 418091 from Patent EP1572962.
JD337030 - Sequence 318054 from Patent EP1572962.
JD279202 - Sequence 260226 from Patent EP1572962.
JD477763 - Sequence 458787 from Patent EP1572962.
JD098397 - Sequence 79421 from Patent EP1572962.
JD342941 - Sequence 323965 from Patent EP1572962.
JD268923 - Sequence 249947 from Patent EP1572962.
JD089773 - Sequence 70797 from Patent EP1572962.
JD552701 - Sequence 533725 from Patent EP1572962.
JD511337 - Sequence 492361 from Patent EP1572962.
JD059006 - Sequence 40030 from Patent EP1572962.
JD302460 - Sequence 283484 from Patent EP1572962.
JD373699 - Sequence 354723 from Patent EP1572962.
JD261886 - Sequence 242910 from Patent EP1572962.
JD128489 - Sequence 109513 from Patent EP1572962.
JD119184 - Sequence 100208 from Patent EP1572962.
JD108136 - Sequence 89160 from Patent EP1572962.
JD126133 - Sequence 107157 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_cdc25Pathway - cdc25 and chk1 Regulatory Pathway in response to DNA damage
h_g2Pathway - Cell Cycle: G2/M Checkpoint
h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation

-  Other Names for This Gene
  Alternate Gene Symbols: E1P5H0, KIAA0835, KIAA1050, MTF1, MYT1_HUMAN, MYTI, NM_004535, NP_004526, O94922, PLPB1, Q01538, Q9UPV2
UCSC ID: uc002yii.3
RefSeq Accession: NM_004535
Protein: Q01538 (aka MYT1_HUMAN)
CCDS: CCDS13558.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004535.2
exon count: 23CDS single in 3' UTR: no RNA size: 5550
ORF size: 3366CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5750.00frame shift in genome: no % Coverage: 99.73
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.