Description: Homo sapiens myelin transcription factor 1 (MYT1), mRNA. RefSeq Summary (NM_004535): The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr20:62,795,827-62,873,606 Size: 77,780 Total Exon Count: 23 Strand: + Coding Region Position: hg19 chr20:62,830,215-62,871,801 Size: 41,587 Coding Exon Count: 21
ID:MYT1_HUMAN DESCRIPTION: RecName: Full=Myelin transcription factor 1; Short=MyT1; AltName: Full=Myelin transcription factor I; Short=MyTI; AltName: Full=PLPB1; AltName: Full=Proteolipid protein-binding protein; FUNCTION: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. SUBUNIT: Interacts with STEAP3. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. DOMAIN: Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence. SIMILARITY: Contains 7 C2HC-type zinc fingers. SEQUENCE CAUTION: Sequence=BAA74858.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01538
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0008270 zinc ion binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0030154 cell differentiation
BC062313 - Homo sapiens myelin transcription factor 1, mRNA (cDNA clone MGC:71389 IMAGE:4301464), complete cds. BC018917 - Homo sapiens myelin transcription factor 1, mRNA (cDNA clone IMAGE:4124248), partial cds. AB020642 - Homo sapiens KIAA0835 mRNA for KIAA0835 protein. JD179036 - Sequence 160060 from Patent EP1572962. JD371801 - Sequence 352825 from Patent EP1572962. JD156330 - Sequence 137354 from Patent EP1572962. JD172839 - Sequence 153863 from Patent EP1572962. JD131295 - Sequence 112319 from Patent EP1572962. JD063754 - Sequence 44778 from Patent EP1572962. CU687528 - Synthetic construct Homo sapiens gateway clone IMAGE:100023027 5' read MYT1 mRNA. KJ901592 - Synthetic construct Homo sapiens clone ccsbBroadEn_10986 MYT1 gene, encodes complete protein. AB385388 - Synthetic construct DNA, clone: pF1KA0835, Homo sapiens MYT1 gene for myelin transcription factor 1, complete cds, without stop codon, in Flexi system. AB028973 - Homo sapiens mRNA for KIAA1050 protein, partial cds. BC053638 - Homo sapiens myelin transcription factor 1, mRNA (cDNA clone IMAGE:4933873), partial cds. M96980 - Homo sapiens myelin transcription factor 1 (MTF1) mRNA, 3' end. JD099323 - Sequence 80347 from Patent EP1572962. JD116472 - Sequence 97496 from Patent EP1572962. JD341635 - Sequence 322659 from Patent EP1572962. JD353412 - Sequence 334436 from Patent EP1572962. JD437067 - Sequence 418091 from Patent EP1572962. JD337030 - Sequence 318054 from Patent EP1572962. JD279202 - Sequence 260226 from Patent EP1572962. JD477763 - Sequence 458787 from Patent EP1572962. JD098397 - Sequence 79421 from Patent EP1572962. JD342941 - Sequence 323965 from Patent EP1572962. JD268923 - Sequence 249947 from Patent EP1572962. JD089773 - Sequence 70797 from Patent EP1572962. JD552701 - Sequence 533725 from Patent EP1572962. JD511337 - Sequence 492361 from Patent EP1572962. JD059006 - Sequence 40030 from Patent EP1572962. JD302460 - Sequence 283484 from Patent EP1572962. JD373699 - Sequence 354723 from Patent EP1572962. JD261886 - Sequence 242910 from Patent EP1572962. JD128489 - Sequence 109513 from Patent EP1572962. JD119184 - Sequence 100208 from Patent EP1572962. JD108136 - Sequence 89160 from Patent EP1572962. JD126133 - Sequence 107157 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cdc25Pathway - cdc25 and chk1 Regulatory Pathway in response to DNA damage h_g2Pathway - Cell Cycle: G2/M Checkpoint h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage h_mPRPathway - How Progesterone Initiates the Oocyte Maturation