Human Gene TEX261 (uc002shn.3)
  Description: Homo sapiens testis expressed 261 (TEX261), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:71,213,068-71,222,001 Size: 8,934 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr2:71,215,730-71,221,887 Size: 6,158 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:71,213,068-71,222,001)mRNA (may differ from genome)Protein (196 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TX261_HUMAN
DESCRIPTION: RecName: Full=Protein TEX261;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the SVP26 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TEX261
CDC HuGE Published Literature: TEX261
Positive Disease Associations: Body Weight
Related Studies:
  1. Body Weight
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 53.34 RPKM in Testis
Total median expression: 1441.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.30114-0.608 Picture PostScript Text
3' UTR -977.982662-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007277 - Transmembrane_adaptor_Erv26

Pfam Domains:
PF04148 - Transmembrane adaptor Erv26

ModBase Predicted Comparative 3D Structure on Q6UWH6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsemblFlyBase SGD
 Protein SequenceProtein SequenceProtein Sequence Protein Sequence
 AlignmentAlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0097020 COPII adaptor activity

Biological Process:
GO:0006888 ER to Golgi vesicle-mediated transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030134 ER to Golgi transport vesicle
GO:0030173 integral component of Golgi membrane
GO:0030176 integral component of endoplasmic reticulum membrane


-  Descriptions from all associated GenBank mRNAs
  LF207234 - JP 2014500723-A/14737: Polycomb-Associated Non-Coding RNAs.
JD038335 - Sequence 19359 from Patent EP1572962.
AL080223 - Homo sapiens mRNA; cDNA DKFZp566H2446 (from clone DKFZp566H2446).
AL832385 - Homo sapiens mRNA; cDNA DKFZp667O1211 (from clone DKFZp667O1211).
BC010656 - Homo sapiens testis expressed sequence 261, mRNA (cDNA clone IMAGE:3855224).
BC020251 - Homo sapiens testis expressed 261, mRNA (cDNA clone IMAGE:4810666), partial cds.
AY358783 - Homo sapiens clone DNA92269 tex261 (UNQ1882) mRNA, complete cds.
AK056410 - Homo sapiens cDNA FLJ31848 fis, clone NT2RP7000579.
AK074840 - Homo sapiens cDNA FLJ90359 fis, clone NT2RP2003655, highly similar to Protein TEX261.
JD159996 - Sequence 141020 from Patent EP1572962.
JD537184 - Sequence 518208 from Patent EP1572962.
JD284368 - Sequence 265392 from Patent EP1572962.
JD224932 - Sequence 205956 from Patent EP1572962.
JD431707 - Sequence 412731 from Patent EP1572962.
JD152737 - Sequence 133761 from Patent EP1572962.
JD110272 - Sequence 91296 from Patent EP1572962.
DQ587692 - Homo sapiens piRNA piR-54804, complete sequence.
DQ587691 - Homo sapiens piRNA piR-54803, complete sequence.
JD174995 - Sequence 156019 from Patent EP1572962.
JD269514 - Sequence 250538 from Patent EP1572962.
JD152834 - Sequence 133858 from Patent EP1572962.
JD165944 - Sequence 146968 from Patent EP1572962.
JD232584 - Sequence 213608 from Patent EP1572962.
DQ580296 - Homo sapiens piRNA piR-48408, complete sequence.
JD276577 - Sequence 257601 from Patent EP1572962.
JD410151 - Sequence 391175 from Patent EP1572962.
JD247437 - Sequence 228461 from Patent EP1572962.
JD267306 - Sequence 248330 from Patent EP1572962.
JD143744 - Sequence 124768 from Patent EP1572962.
JD161108 - Sequence 142132 from Patent EP1572962.
JD324912 - Sequence 305936 from Patent EP1572962.
JD189689 - Sequence 170713 from Patent EP1572962.
LF363346 - JP 2014500723-A/170849: Polycomb-Associated Non-Coding RNAs.
JD147247 - Sequence 128271 from Patent EP1572962.
JD138195 - Sequence 119219 from Patent EP1572962.
JD327084 - Sequence 308108 from Patent EP1572962.
JD331357 - Sequence 312381 from Patent EP1572962.
LF363347 - JP 2014500723-A/170850: Polycomb-Associated Non-Coding RNAs.
JD164618 - Sequence 145642 from Patent EP1572962.
JD519817 - Sequence 500841 from Patent EP1572962.
JD322320 - Sequence 303344 from Patent EP1572962.
JD507754 - Sequence 488778 from Patent EP1572962.
JD385348 - Sequence 366372 from Patent EP1572962.
JD438178 - Sequence 419202 from Patent EP1572962.
JD092760 - Sequence 73784 from Patent EP1572962.
JD187314 - Sequence 168338 from Patent EP1572962.
JD450805 - Sequence 431829 from Patent EP1572962.
JD147000 - Sequence 128024 from Patent EP1572962.
JD133364 - Sequence 114388 from Patent EP1572962.
JD557117 - Sequence 538141 from Patent EP1572962.
JD112790 - Sequence 93814 from Patent EP1572962.
JD277716 - Sequence 258740 from Patent EP1572962.
JD289480 - Sequence 270504 from Patent EP1572962.
JD510611 - Sequence 491635 from Patent EP1572962.
JD215735 - Sequence 196759 from Patent EP1572962.
JD126171 - Sequence 107195 from Patent EP1572962.
JD310252 - Sequence 291276 from Patent EP1572962.
JD380726 - Sequence 361750 from Patent EP1572962.
JD546622 - Sequence 527646 from Patent EP1572962.
JD204341 - Sequence 185365 from Patent EP1572962.
JD481931 - Sequence 462955 from Patent EP1572962.
JD353734 - Sequence 334758 from Patent EP1572962.
JD193315 - Sequence 174339 from Patent EP1572962.
JD498730 - Sequence 479754 from Patent EP1572962.
JD276851 - Sequence 257875 from Patent EP1572962.
JD423465 - Sequence 404489 from Patent EP1572962.
JD276838 - Sequence 257862 from Patent EP1572962.
JD151580 - Sequence 132604 from Patent EP1572962.
AK303594 - Homo sapiens cDNA FLJ56309 complete cds, highly similar to Protein TEX261.
JD204128 - Sequence 185152 from Patent EP1572962.
JD157817 - Sequence 138841 from Patent EP1572962.
JD298791 - Sequence 279815 from Patent EP1572962.
JD051874 - Sequence 32898 from Patent EP1572962.
JD133830 - Sequence 114854 from Patent EP1572962.
LF363348 - JP 2014500723-A/170851: Polycomb-Associated Non-Coding RNAs.
JD501749 - Sequence 482773 from Patent EP1572962.
JD111949 - Sequence 92973 from Patent EP1572962.
JD276031 - Sequence 257055 from Patent EP1572962.
JD277858 - Sequence 258882 from Patent EP1572962.
JD290396 - Sequence 271420 from Patent EP1572962.
JD426173 - Sequence 407197 from Patent EP1572962.
JD429433 - Sequence 410457 from Patent EP1572962.
JD248316 - Sequence 229340 from Patent EP1572962.
JD482927 - Sequence 463951 from Patent EP1572962.
JD368955 - Sequence 349979 from Patent EP1572962.
LF363349 - JP 2014500723-A/170852: Polycomb-Associated Non-Coding RNAs.
JD202162 - Sequence 183186 from Patent EP1572962.
BC128461 - Homo sapiens testis expressed 261, mRNA (cDNA clone MGC:156306 IMAGE:40126644), complete cds.
BC128462 - Homo sapiens testis expressed 261, mRNA (cDNA clone MGC:156307 IMAGE:40126645), complete cds.
JD074533 - Sequence 55557 from Patent EP1572962.
LF363350 - JP 2014500723-A/170853: Polycomb-Associated Non-Coding RNAs.
JD044121 - Sequence 25145 from Patent EP1572962.
AK315543 - Homo sapiens cDNA, FLJ96610, Homo sapiens testis expressed gene 261 (TEX261), mRNA.
KJ904958 - Synthetic construct Homo sapiens clone ccsbBroadEn_14352 TEX261 gene, encodes complete protein.
KJ895254 - Synthetic construct Homo sapiens clone ccsbBroadEn_04648 TEX261 gene, encodes complete protein.
LF363352 - JP 2014500723-A/170855: Polycomb-Associated Non-Coding RNAs.
LF363354 - JP 2014500723-A/170857: Polycomb-Associated Non-Coding RNAs.
MA598923 - JP 2018138019-A/170849: Polycomb-Associated Non-Coding RNAs.
MA598924 - JP 2018138019-A/170850: Polycomb-Associated Non-Coding RNAs.
MA598925 - JP 2018138019-A/170851: Polycomb-Associated Non-Coding RNAs.
MA598926 - JP 2018138019-A/170852: Polycomb-Associated Non-Coding RNAs.
MA598927 - JP 2018138019-A/170853: Polycomb-Associated Non-Coding RNAs.
MA598929 - JP 2018138019-A/170855: Polycomb-Associated Non-Coding RNAs.
MA598931 - JP 2018138019-A/170857: Polycomb-Associated Non-Coding RNAs.
MA442811 - JP 2018138019-A/14737: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A587, D6W5G9, NM_144582, NP_653183, Q6UWH6, Q8WUJ5, TX261_HUMAN, UNQ1882/PRO4325
UCSC ID: uc002shn.3
RefSeq Accession: NM_144582
Protein: Q6UWH6 (aka TX261_HUMAN)
CCDS: CCDS1914.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_144582.2
exon count: 6CDS single in 3' UTR: no RNA size: 3381
ORF size: 591CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1382.00frame shift in genome: no % Coverage: 99.59
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.