Human Gene N4BP2L2 (uc010abe.1)
  Description: Homo sapiens NEDD4 binding protein 2-like 2 (N4BP2L2), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr13:33,006,930-33,112,936 Size: 106,007 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr13:33,010,519-33,111,164 Size: 100,646 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:33,006,930-33,112,936)mRNA (may differ from genome)Protein (752 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIOMIM
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.73 RPKM in Ovary
Total median expression: 642.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.1022-0.095 Picture PostScript Text
3' UTR -48.70201-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q92802-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  U50529 - Human BRCA2 region, mRNA sequence CG016.
AK093514 - Homo sapiens cDNA FLJ36195 fis, clone TESTI2027645.
AK298546 - Homo sapiens cDNA FLJ55497 complete cds.
AK310280 - Homo sapiens cDNA, FLJ17322.
AL049802 - Novel human gene mapping to chomosome 13.
AK125067 - Homo sapiens cDNA FLJ43077 fis, clone BRTHA3015910.
BC131631 - Homo sapiens NEDD4 binding protein 2-like 2, mRNA (cDNA clone IMAGE:40118858), partial cds.
JD084232 - Sequence 65256 from Patent EP1572962.
FW553754 - IRNA AGENTS TARGETING VEGF.
FW553755 - IRNA AGENTS TARGETING VEGF.
FW553756 - IRNA AGENTS TARGETING VEGF.
HI963460 - Sequence 390 from Patent EP1735009.
HI963461 - Sequence 391 from Patent EP1735009.
HI963462 - Sequence 392 from Patent EP1735009.
HV496699 - JP 2011518117-A/1927: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496700 - JP 2011518117-A/1928: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV496701 - JP 2011518117-A/1929: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HV983082 - JP 2011188866-A/390: IRNA AGENTS TARGETING VEGF.
HV983083 - JP 2011188866-A/391: IRNA AGENTS TARGETING VEGF.
HV983084 - JP 2011188866-A/392: IRNA AGENTS TARGETING VEGF.
HZ402216 - JP 2015177801-A/1927: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ402217 - JP 2015177801-A/1928: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ402218 - JP 2015177801-A/1929: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES.
HZ420313 - JP 2014094020-A/390: IRNA AGENTS TARGETING VEGF.
HZ420314 - JP 2014094020-A/391: IRNA AGENTS TARGETING VEGF.
HZ420315 - JP 2014094020-A/392: IRNA AGENTS TARGETING VEGF.
LZ247484 - JP 2016135144-A/390: IRNA AGENTS TARGETING VEGF.
LZ247485 - JP 2016135144-A/391: IRNA AGENTS TARGETING VEGF.
LZ247486 - JP 2016135144-A/392: IRNA AGENTS TARGETING VEGF.
AK123084 - Homo sapiens cDNA FLJ41089 fis, clone ASTRO2003574.
AL049783 - Novel human gene mapping to chomosome 13.
AL832581 - Homo sapiens mRNA; cDNA DKFZp451G1516 (from clone DKFZp451G1516).
BC010643 - Homo sapiens NEDD4 binding protein 2-like 2, mRNA (cDNA clone MGC:9499 IMAGE:3852778), complete cds.
U50532 - Human BRCA2 region, mRNA sequence CG005.
AF530063 - Homo sapiens phosphonoformate immuno-associated protein 5 (PFAAP5) mRNA, complete cds.
AK312924 - Homo sapiens cDNA, FLJ93374.
BT007172 - Homo sapiens hypothetical protein from BCRA2 region mRNA, complete cds.
DQ890625 - Synthetic construct clone IMAGE:100003255; FLH164450.01X; RZPDo839G05162D phosphonoformate immuno-associated protein 5 (PFAAP5) gene, encodes complete protein.
KJ893041 - Synthetic construct Homo sapiens clone ccsbBroadEn_02435 N4BP2L2 gene, encodes complete protein.
EU176484 - Synthetic construct Homo sapiens clone IMAGE:100011336; FLH164449.01L; RZPDo839E02253D phosphonoformate immuno-associated protein 5 (PFAAP5) gene, encodes complete protein.
CU679777 - Synthetic construct Homo sapiens gateway clone IMAGE:100019909 5' read PFAAP5 mRNA.
Z36834 - H.sapiens (xs7) mRNA, 407bp.

-  Other Names for This Gene
  Alternate Gene Symbols: CG005, NM_033111, NP_149102, PFAAP5, Q92802-3
UCSC ID: uc010abe.1
RefSeq Accession: NM_033111
Protein: Q92802-3, splice isoform of Q92802 CCDS: CCDS45024.1, CCDS61307.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033111.3
exon count: 10CDS single in 3' UTR: no RNA size: 2482
ORF size: 2259CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4705.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.