Human Gene DNAJC17 (uc001zms.2)
  Description: Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 17 (DNAJC17), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:41,060,067-41,099,676 Size: 39,610 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr15:41,060,138-41,099,644 Size: 39,507 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:41,060,067-41,099,676)mRNA (may differ from genome)Protein (304 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DJC17_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 17;
SIMILARITY: Contains 1 J domain.
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DNAJC17
CDC HuGE Published Literature: DNAJC17

-  MalaCards Disease Associations
  MalaCards Gene Search: DNAJC17
Diseases sorted by gene-association score: ileocolitis (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.64 RPKM in Cervix - Endocervix
Total median expression: 273.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.3032-0.134 Picture PostScript Text
3' UTR -0.5071-0.007 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR003095 - Hsp_DnaJ
IPR012677 - Nucleotide-bd_a/b_plait

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00226 - DnaJ domain
PF13893 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

SCOP Domains:
46565 - Chaperone J-domain
54928 - RNA-binding domain, RBD

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2D9O - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9NVM6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:1901998 toxin transport

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK001496 - Homo sapiens cDNA FLJ10634 fis, clone NT2RP2005654, weakly similar to CYSTEINE STRING PROTEIN.
BC000048 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 17, mRNA (cDNA clone MGC:944 IMAGE:3507470), complete cds.
JD387772 - Sequence 368796 from Patent EP1572962.
KJ894152 - Synthetic construct Homo sapiens clone ccsbBroadEn_03546 DNAJC17 gene, encodes complete protein.
AB528922 - Synthetic construct DNA, clone: pF1KE0715, Homo sapiens DNAJC17 gene for DnaJ (Hsp40) homolog, subfamily C, member 17, without stop codon, in Flexi system.
AK309307 - Homo sapiens cDNA, FLJ99348.
AK308858 - Homo sapiens cDNA, FLJ98899.
AK308659 - Homo sapiens cDNA, FLJ98700.
AK310140 - Homo sapiens cDNA, FLJ17182.
LF205845 - JP 2014500723-A/13348: Polycomb-Associated Non-Coding RNAs.
LF348840 - JP 2014500723-A/156343: Polycomb-Associated Non-Coding RNAs.
MA584417 - JP 2018138019-A/156343: Polycomb-Associated Non-Coding RNAs.
MA441422 - JP 2018138019-A/13348: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DJC17_HUMAN, NM_018163, NP_060633, Q9NVM6
UCSC ID: uc001zms.2
RefSeq Accession: NM_018163
Protein: Q9NVM6 (aka DJC17_HUMAN)
CCDS: CCDS10065.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_018163.2
exon count: 11CDS single in 3' UTR: no RNA size: 1031
ORF size: 915CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2030.00frame shift in genome: no % Coverage: 98.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.